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Gene Information
Gene symbol: PTGES3
Gene name: prostaglandin E synthase 3 (cytosolic)
HGNC ID: 16049
Synonyms: p23, TEBP, cPGES
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ANP32A | 1 hits |
| 2 | PPP2R4 | 1 hits |
| 3 | SET | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21502318 | The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network. |
| 2 | 21502318 | The angiotensin II peptide analog [Sar(1),Ile(4),Ile(8)]AngII (SII) is a biased AT(1A) receptor agonist that stimulates receptor phosphorylation, β-arrestin recruitment, receptor internalization, and β-arrestin-dependent ERK1/2 activation without activating heterotrimeric G-proteins. |
| 3 | 21502318 | To determine the scope of G-protein-independent AT(1A) receptor signaling, we performed a gel-based phosphoproteomic analysis of AngII and SII-induced signaling in HEK cells stably expressing AT(1A) receptors. |
| 4 | 21502318 | MALDI-TOF/TOF mass fingerprinting was employed to identify 24 SII-sensitive phosphoprotein spots, of which three (two peptide inhibitors of protein phosphatase 2A (I1PP2A and I2PP2A) and prostaglandin E synthase 3 (PGES3)) were selected for validation and further study. |
| 5 | 21502318 | We found that phosphorylation of I2PP2A was associated with rapid and transient inhibition of a β-arrestin 2-associated pool of protein phosphatase 2A, leading to activation of Akt and increased phosphorylation of glycogen synthase kinase 3β in an arrestin signalsome complex. |