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Gene Information
Gene symbol: PTPN5
Gene name: protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
HGNC ID: 9657
Synonyms: STEP, PTPSTEP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MAPK1 | 1 hits |
| 2 | PTPN7 | 1 hits |
| 3 | PTPRR | 1 hits |
| 4 | PTPRU | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16919785 | Many PTPs are recognized as potential drug targets; however, inhibitor development has focused only on a small number of enzymes, most notably PTP1B for type II diabetes and obesity, and MKP1 and CDC25 for cancer. |
| 2 | 16919785 | In this article, we focus on the family of mitogen-activated protein kinase (MAPK)-specific tyrosine phosphatases--PTPN5 [also called striatal-enriched phosphatase (STEP)], PTPN7 (also called hematopoietic PTP) and PTPRR (also called PC12 PTP or STEP-like PTP)--and discuss approaches for achieving selectivity for the MAPK-PTPs at the molecular level using recently determined high-resolution X-ray crystal structures. |