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Gene Information

Gene symbol: PYDC1

Gene name: PYD (pyrin domain) containing 1

HGNC ID: 30261

Synonyms: ASC2, POP1

Related Genes

#	Gene Symbol	Number of hits
1	CASP1	1 hits
2	IL18	1 hits
3	IL1B	1 hits
4	MEFV	1 hits
5	NLRP1	1 hits
6	NLRP3	1 hits
7	PYCARD	1 hits

Related Sentences

#	PMID	Sentence
1	23066025	Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.
2	23066025	A key process underlying an innate immune response to pathogens or cellular stress is activation of members of the NOD-like receptor family, such as NLRP3, to assemble caspase-1-activating inflammasome complexes.
3	23066025	ASC interacts with NLRP3 via a homotypic PYD interaction and recruits procaspase-1 via a homotypic caspase recruitment domain interaction.
4	23066025	Here we demonstrate that ASC PYD contains two distinct binding sites important for self-association and interaction with NLRP3 and the modulatory protein POP1.
5	23066025	Furthermore, a type I binding mode is likely conserved in interactions with NLRP3 and POP1, because residues critical for interaction of ASC PYD are conserved in these PYDs.
6	23066025	We also demonstrate that ASC PYD can simultaneously self-associate and interact with NLRP3, rationalizing the model whereby ASC self-association upon recruitment to NLRP3 promotes clustering and activation of procaspase-1.
7	23066025	Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.
8	23066025	A key process underlying an innate immune response to pathogens or cellular stress is activation of members of the NOD-like receptor family, such as NLRP3, to assemble caspase-1-activating inflammasome complexes.
9	23066025	ASC interacts with NLRP3 via a homotypic PYD interaction and recruits procaspase-1 via a homotypic caspase recruitment domain interaction.
10	23066025	Here we demonstrate that ASC PYD contains two distinct binding sites important for self-association and interaction with NLRP3 and the modulatory protein POP1.
11	23066025	Furthermore, a type I binding mode is likely conserved in interactions with NLRP3 and POP1, because residues critical for interaction of ASC PYD are conserved in these PYDs.
12	23066025	We also demonstrate that ASC PYD can simultaneously self-associate and interact with NLRP3, rationalizing the model whereby ASC self-association upon recruitment to NLRP3 promotes clustering and activation of procaspase-1.
13	23852602	Pathogen-stimulated NLRs such as NLR family Pyrin domain-containing protein 1 (NLRP1) assemble into molecular platforms called "inflammasomes" to activate inflammatory protease caspase-1, which processes pro-IL-1β and pro-IL-18 into active cytokines.
14	23852602	Protocols are provided for: (a) expression and purification of inflammasome core components (NLRP1 and pro-caspase-1 proteins) using the baculovirus/insect cell expression system, and (b) functional monitoring of NLRP1-mediated caspase-1 activation in response to NLRP1 ligand muramyl dipeptide (MDP) and ATP.