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Gene Information
Gene symbol: RAB3GAP1
Gene name: RAB3 GTPase activating protein subunit 1 (catalytic)
HGNC ID: 17063
Synonyms: RAB3GAP, KIAA0066, RAB3GAP130, WARBM1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACMSD | 1 hits |
| 2 | MAPK3 | 1 hits |
| 3 | PTK2 | 1 hits |
| 4 | PTPN1 | 1 hits |
| 5 | SRC | 1 hits |
| 6 | SRPR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15866871 | Protein-tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin and leptin signaling and a novel therapeutic target for the treatment of type 2 diabetes, obesity, and other associated metabolic syndromes. |
| 2 | 15866871 | We show that down-regulation of PTP1B activity with small molecule inhibitors suppresses cell spreading and migration to fibronectin, increases Tyr(527) phosphorylation in Src, and decreases phosphorylation of FAK, p130(Cas), and ERK1/2. |
| 3 | 15866871 | We also show that PTP1B forms a complex with Src and p130(Cas), and that the proline-rich motif PPRPPK (residues 309-314) in PTP1B is essential for the complex formation. |
| 4 | 15866871 | We suggest that the specificity of PTP1B for Src pTyr(527) is mediated by protein-protein interactions involving the docking protein p130(Cas) with both Src and PTP1B in addition to the interactions between the PTP1B active site and the pTyr(527) motif. |
| 5 | 15866871 | Protein-tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin and leptin signaling and a novel therapeutic target for the treatment of type 2 diabetes, obesity, and other associated metabolic syndromes. |
| 6 | 15866871 | We show that down-regulation of PTP1B activity with small molecule inhibitors suppresses cell spreading and migration to fibronectin, increases Tyr(527) phosphorylation in Src, and decreases phosphorylation of FAK, p130(Cas), and ERK1/2. |
| 7 | 15866871 | We also show that PTP1B forms a complex with Src and p130(Cas), and that the proline-rich motif PPRPPK (residues 309-314) in PTP1B is essential for the complex formation. |
| 8 | 15866871 | We suggest that the specificity of PTP1B for Src pTyr(527) is mediated by protein-protein interactions involving the docking protein p130(Cas) with both Src and PTP1B in addition to the interactions between the PTP1B active site and the pTyr(527) motif. |
| 9 | 15866871 | Protein-tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin and leptin signaling and a novel therapeutic target for the treatment of type 2 diabetes, obesity, and other associated metabolic syndromes. |
| 10 | 15866871 | We show that down-regulation of PTP1B activity with small molecule inhibitors suppresses cell spreading and migration to fibronectin, increases Tyr(527) phosphorylation in Src, and decreases phosphorylation of FAK, p130(Cas), and ERK1/2. |
| 11 | 15866871 | We also show that PTP1B forms a complex with Src and p130(Cas), and that the proline-rich motif PPRPPK (residues 309-314) in PTP1B is essential for the complex formation. |
| 12 | 15866871 | We suggest that the specificity of PTP1B for Src pTyr(527) is mediated by protein-protein interactions involving the docking protein p130(Cas) with both Src and PTP1B in addition to the interactions between the PTP1B active site and the pTyr(527) motif. |
| 13 | 23209189 | TMEM163 variants also showed association with decreased fasting plasma insulin and homeostatic model assessment of insulin resistance, indicating a plausible effect through impaired insulin secretion. |
| 14 | 23209189 | The 2q21 region also harbors RAB3GAP1 and ACMSD; those are involved in neurologic disorders. |