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Gene Information
Gene symbol: RALA
Gene name: v-ral simian leukemia viral oncogene homolog A (ras related)
HGNC ID: 9839
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CDC42 | 1 hits |
| 3 | RALBP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11728382 | In the present study, we have shown that exposure of insulin-secreting clonal beta (HIT-T15) cells to interleukin-1beta (IL-1beta) results in a time- and concentration-dependent increase in nitric oxide (NO) release. |
| 2 | 11728382 | These effects by IL-1beta on NO release were mediated by induction of inducible nitric oxide synthase (iNOS) from the cells. |
| 3 | 11728382 | Preincubation of HIT cells with Clostridium sordellii lethal toxin-82, which irreversibly glucosylates and inactivates small G-proteins, such as Ras, Rap, Ral, and Rac, but not Cdc42, completely abolished IL-1beta-induced NO release. |
| 4 | 11728382 | Pre-exposure of HIT cells to C. sordellii lethal toxin-9048, which monoglucosylates and inhibits Ras, Cdc42, Rac, and Rap, but not Ral, also attenuated IL-1beta-mediated NO release. |
| 5 | 11728382 | Preincubation of HIT cells with C. difficile toxin-B, which monoglucosylates Rac, Cdc42, and Rho, had no demonstrable effects on IL-mediated NO release, ruling out the possibility that Rac may be involved in this signaling step. |
| 6 | 23419874 | P300 regulates the human RLIP76 promoter activity and gene expression. |
| 7 | 23419874 | A 76-kDa Ral-interacting protein (RLIP76) has been implicated in the pathogenesis of cancer and diabetes. |
| 8 | 23419874 | RLIP76 homozygous knockout mice exhibit increased insulin sensitivity, hypoglycemia, and hypolipidemia, and resist cancer development. |
| 9 | 23419874 | Transcription factor cMYB and the coactivator p300 associated with RLIP76 gene promoter as shown by CHIP assay. |
| 10 | 23419874 | Knockdown of p300 also decreased the RLIP76 expression as indicated by immunoblotting, immunocytochemistry and flow cytometry analysis. |
| 11 | 23419874 | Thus, we report for the first time that p300 associates with the RLIP76 promoter via an overlapping cMYB and cETS binding site and regulates RLIP76 promoter activity and its expression. |