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Gene Information
Gene symbol: RAP2B
Gene name: RAP2B, member of RAS oncogene family
HGNC ID: 9862
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | RAP1B | 1 hits |
| 2 | RAP2A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12196513 | High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway. |
| 2 | 12196513 | This investigation describes the effect of high glucose (HG) on a small GTP-binding protein, Rap1b, expression and activation, and the relevance of protein kinase C (PKC) and Raf pathways in fibronectin synthesis in cultured renal glomerular mesangial cells (MCs). |
| 3 | 12196513 | B-Raf and Raf-1 expression was investigated to assess whether Rap1b effects are mediated via the Raf pathway. |
| 4 | 12196513 | B-Raf, and not Raf-1, expression was increased in MCs transfected with Rap1b. |
| 5 | 12196513 | HG also caused activation of Rap1b, which was largely unaffected by anti-platelet-derived growth factor (PDGF) antibodies. |
| 6 | 12196513 | HG-induced activation of Rap1b was specific, since Rap2b activation and expression of Rap2a and Rap2b were unaffected by HG. |
| 7 | 12196513 | This effect appears to be PKC-dependent and PDGF-independent, but involves B-Raf, suggesting a novel PKC-Rap1b-B-Raf pathway responsible for HG-induced increased mesangial matrix synthesis, a hallmark of diabetic nephropathy. |