- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: RBX1
Gene name: ring-box 1, E3 ubiquitin protein ligase
HGNC ID: 9928
Synonyms: ROC1, RNF75, BA554C12.1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CUL1 | 1 hits |
| 2 | FBXO25 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11717410 | Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. |
| 2 | 11717410 | It contains a functional F-box domain that binds to Skp1 and thereby to Roc1 and Cul1, the other components of SCF-type Ub-protein ligases (E3s), as well as a nuclear localization sequence and PDZ-binding domain. |
| 3 | 11717410 | Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases. |
| 4 | 16714087 | FBXO25, an F-box protein homologue of atrogin-1, is not induced in atrophying muscle. |
| 5 | 16714087 | Atrogin-1/MAFbx/FBXO32 is a muscle-specific ubiquitin-ligase (E3) that is dramatically increased in atrophying muscle. |
| 6 | 16714087 | Here, we have investigated the functional relationship between atrogin-1 and FBXO25 which shares 65% amino acid identity. |
| 7 | 16714087 | Using a RT-PCR, we demonstrated that FBXO25 is highly expressed in brain, kidney, and intestine, whereas atrogin-1 expression is largely restricted to striate muscle. |
| 8 | 16714087 | FBXO25 was shown here to contain a functional F-box domain that binds to Skp1 and thereby to Roc1 and Cul1, the major components of SCF-type E3s. |
| 9 | 16714087 | In addition, the productive SCF complex containing FBXO25 showed ubiquitin ligase activity. |
| 10 | 16714087 | We investigated the differential expression of atrogin-1 and FBXO25 in fasted and dexamethasone-treated mice and also in rats with streptozotocin-induced diabetes. |
| 11 | 16714087 | Although the atrogin-1 was strongly induced in muscle in all three models, no changes were observed in the expression of FBXO25. |
| 12 | 16714087 | Therefore, here we have shown that FBXO25 is a novel F-box protein analogous to atrogin-1, which is not involved in muscle atrophy. |
| 13 | 16714087 | Further functional studies should elucidate the exact role of FBXO25 in the ubiquitin-proteasome pathway. |