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Gene Information
Gene symbol: RIPK3
Gene name: receptor-interacting serine-threonine kinase 3
HGNC ID: 10021
Synonyms: RIP3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CRTC2 | 1 hits |
| 2 | GSTCD | 1 hits |
| 3 | HNF4A | 1 hits |
| 4 | MAPKAP1 | 1 hits |
| 5 | ZNHIT3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11916906 | Mutations of the hepatocyte nuclear factor-4alpha (HNF-4alpha) gene are associated with a subtype of maturity-onset diabetes of the young (MODY1) that is characterized by impaired insulin secretion in response to a glucose load. |
| 2 | 11916906 | In the present study, we showed, using a yeast two-hybrid screening assay, that thyroid hormone receptor interacting protein 3 (Trip3) interacted with HNF-4alpha, and their interaction was confirmed by the glutathione S-transferase pull-down assay. |
| 3 | 11916906 | Cotransfection experiments indicated that Trip3 could enhance (two- to threefold) the transcription activity of HNF-4alpha in COS-7 cells and MIN6 cells. |
| 4 | 11916906 | These results suggest that Trip3 is a coactivator of HNF-4alpha. |
| 5 | 11916906 | Mutation screening revealed that variation of the Trip3 gene is not a common cause of MODY/early-onset type 2 diabetes in Japanese individuals. |
| 6 | 11916906 | Trip3 may play an important role in glucose metabolism by regulating the transcription activity of HNF-4alpha. |
| 7 | 17656577 | The zinc finger HIT domain is a sequence motif found in many proteins, including thyroid hormone receptor interacting protein 3 (TRIP-3), which is possibly involved in maturity-onset diabetes of the young (MODY). |
| 8 | 22266904 | TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. |
| 9 | 22266904 | The TOR protein kinase functions in two distinct complexes, TOR complex 1 (TORC1) and 2 (TORC2). |
| 10 | 22266904 | TORC1 is required for growth in response to growth factors, nutrients and the cellular energy state; TORC2 regulates AKT signaling, which can modulate cytoskeletal polarization. |
| 11 | 22266904 | However, loss of Dictyostelium TORC2 components Rictor/Pia, SIN1/RIP3 and Lst8 promotes nutrient particle uptake; inactivation of TORC2 leads to increased efficiency and speed of phagocytosis. |
| 12 | 22266904 | In contrast to phagocytosis, we show that macropinocytosis, an AKT-dependent process for cellular uptake of fluid phase nutrients, is not regulated by either of the TOR complexes. |
| 13 | 22266904 | The integrated and balanced regulation of TORC1 and TORC2 might be crucial in Dictyostelium to coordinate growth and energy needs with other essential TOR-regulated processes. |