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Gene Information
Gene symbol: RNF19A
Gene name: ring finger protein 19A, E3 ubiquitin protein ligase
HGNC ID: 13432
Synonyms: dorfin, DKFZp566B1346
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MAPK14 | 1 hits |
| 2 | MYEF2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15111488 | Overexpression of GLUT4 in skeletal muscle enhances whole-body insulin action. |
| 2 | 15111488 | Exercise increases GLUT4 gene and protein expression, and a binding site for the myocyte enhancer factor 2 (MEF-2) is required on the GLUT4 promoter for this response. |
| 3 | 15111488 | In various cell systems, MEF-2 regulation is a balance between transcriptional repression by histone deacetylases (HDACs) and transcriptional activation by the nuclear factor of activated T-cells (NFAT), peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1), and the p38 mitogen-activated protein kinase. |
| 4 | 15111488 | After exercise, HDAC5 was dissociated from MEF-2 and exported from the nucleus, whereas nuclear PGC-1 was associated with MEF-2. |
| 5 | 15111488 | Exercise increased total and nuclear p38 phosphorylation and association with MEF-2, without changes in total or nuclear p38 protein abundance. |
| 6 | 15111488 | This result was associated with p38 sequence-specific phosphorylation of MEF-2 and an increase in GLUT4 mRNA. |
| 7 | 15111488 | From these data, it appears that HDAC5, PGC-1, and p38 regulate MEF-2 and could be potential targets for modulating GLUT4 expression. |