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Gene Information
Gene symbol: RNF216
Gene name: ring finger protein 216
HGNC ID: 21698
Synonyms: TRIAD3, U7I1, UBCE7IP1, ZIN
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EIF4ENIF1 | 1 hits |
| 2 | GTF2A1 | 1 hits |
| 3 | RPS27A | 1 hits |
| 4 | TBP | 1 hits |
| 5 | UBL5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19609011 | Regarding protein metabolism a marked downregulation in gene transcripts for: general transcription factor IIA1 (-1.88, P=0.016309), TATA box binding protein (-2.17, P=0.037373), eukaryotic translation initiation factor 4E nuclear import factor 1 (-1.61, P=0.037373), eukaryotic translation elongation factor Ibeta2 (-1.95, P=0.010406), ubiquitin-like 5 (-1.67, P=0.024975) and ubiquitin conjugating enzyme 7 interacting protein 1 (-1.68, P=0.016309) was observed. |
| 2 | 19609011 | STZ-diabetes caused a drop in the expression of myogenin, whereas myostatin level was significantly elevated. |
| 3 | 19609011 | In conclusion, 1) STZ-diabetes attenuates expression of gene transcripts involved in the process of transcription and translation, which may affect skeletal muscle protein synthesis and lead to nitrogen imbalance, 2) impaired expression of gene transcripts involved in the regulation and activity of the ubiquitin-proteasome pathway may contribute to attenuation of mechanisms eliminating damaged proteins in STZ-diabetes, 3) changes in the expression of key myogenic factors, manifested by a decrease in myogenin level and enhancement of myostatin expression may be one of the mechanisms limiting skeletal muscle growth and regeneration associated with diabetes. |