Ignet

Gene Information

Gene symbol: RPE65

Gene name: retinal pigment epithelium-specific protein 65kDa

HGNC ID: 10294

Synonyms: LCA2, rd12

Related Genes

#	Gene Symbol	Number of hits
1	ACTB	1 hits
2	LRAT	1 hits
3	OPN4	1 hits
4	RS1	1 hits

Related Sentences

#	PMID	Sentence
1	18837955	In patients with preproliferative or proliferative DR, median levels for rhodopsin mRNA and RPE65 mRNA were 30% and 80% higher and retinoschisin mRNA was lower in patients with >/=5 dips/hr when compared to patients with <5 dips/hr.
2	18837956	The markers were RPE65, retinoschisin, and melanopsin.
3	18837956	Quantitative real-time PCR was used to quantify mRNA for RPE65, retinoschisin, and melanopsin. beta-actin mRNA was used for normalization.
4	18837956	RPE65, retinoschisin, and beta-actin mRNA were detected in 100% of subjects; melanopsin was not detected in either controls or diabetic patients.
5	18837956	Circulating RPE65 mRNA concentration was 63% higher in diabetic patients than in healthy individuals (P= 0.019), whereas retinoschisin showed no change between the two groups.
6	18837956	Both RPE65 and retinoschisin were detectable and demonstrated contrasting trends in diabetics with and without retinopathy.
7	18837956	In combination with rhodopsin, RPE65, and retinoschisin, mRNA may offer a useful tool in developing a blood test for DR.
8	18837956	The markers were RPE65, retinoschisin, and melanopsin.
9	18837956	Quantitative real-time PCR was used to quantify mRNA for RPE65, retinoschisin, and melanopsin. beta-actin mRNA was used for normalization.
10	18837956	RPE65, retinoschisin, and beta-actin mRNA were detected in 100% of subjects; melanopsin was not detected in either controls or diabetic patients.
11	18837956	Circulating RPE65 mRNA concentration was 63% higher in diabetic patients than in healthy individuals (P= 0.019), whereas retinoschisin showed no change between the two groups.
12	18837956	Both RPE65 and retinoschisin were detectable and demonstrated contrasting trends in diabetics with and without retinopathy.
13	18837956	In combination with rhodopsin, RPE65, and retinoschisin, mRNA may offer a useful tool in developing a blood test for DR.
14	18837956	The markers were RPE65, retinoschisin, and melanopsin.
15	18837956	Quantitative real-time PCR was used to quantify mRNA for RPE65, retinoschisin, and melanopsin. beta-actin mRNA was used for normalization.
16	18837956	RPE65, retinoschisin, and beta-actin mRNA were detected in 100% of subjects; melanopsin was not detected in either controls or diabetic patients.
17	18837956	Circulating RPE65 mRNA concentration was 63% higher in diabetic patients than in healthy individuals (P= 0.019), whereas retinoschisin showed no change between the two groups.
18	18837956	Both RPE65 and retinoschisin were detectable and demonstrated contrasting trends in diabetics with and without retinopathy.
19	18837956	In combination with rhodopsin, RPE65, and retinoschisin, mRNA may offer a useful tool in developing a blood test for DR.
20	18837956	The markers were RPE65, retinoschisin, and melanopsin.
21	18837956	Quantitative real-time PCR was used to quantify mRNA for RPE65, retinoschisin, and melanopsin. beta-actin mRNA was used for normalization.
22	18837956	RPE65, retinoschisin, and beta-actin mRNA were detected in 100% of subjects; melanopsin was not detected in either controls or diabetic patients.
23	18837956	Circulating RPE65 mRNA concentration was 63% higher in diabetic patients than in healthy individuals (P= 0.019), whereas retinoschisin showed no change between the two groups.
24	18837956	Both RPE65 and retinoschisin were detectable and demonstrated contrasting trends in diabetics with and without retinopathy.
25	18837956	In combination with rhodopsin, RPE65, and retinoschisin, mRNA may offer a useful tool in developing a blood test for DR.
26	18837956	The markers were RPE65, retinoschisin, and melanopsin.
27	18837956	Quantitative real-time PCR was used to quantify mRNA for RPE65, retinoschisin, and melanopsin. beta-actin mRNA was used for normalization.
28	18837956	RPE65, retinoschisin, and beta-actin mRNA were detected in 100% of subjects; melanopsin was not detected in either controls or diabetic patients.
29	18837956	Circulating RPE65 mRNA concentration was 63% higher in diabetic patients than in healthy individuals (P= 0.019), whereas retinoschisin showed no change between the two groups.
30	18837956	Both RPE65 and retinoschisin were detectable and demonstrated contrasting trends in diabetics with and without retinopathy.
31	18837956	In combination with rhodopsin, RPE65, and retinoschisin, mRNA may offer a useful tool in developing a blood test for DR.
32	18837956	The markers were RPE65, retinoschisin, and melanopsin.
33	18837956	Quantitative real-time PCR was used to quantify mRNA for RPE65, retinoschisin, and melanopsin. beta-actin mRNA was used for normalization.
34	18837956	RPE65, retinoschisin, and beta-actin mRNA were detected in 100% of subjects; melanopsin was not detected in either controls or diabetic patients.
35	18837956	Circulating RPE65 mRNA concentration was 63% higher in diabetic patients than in healthy individuals (P= 0.019), whereas retinoschisin showed no change between the two groups.
36	18837956	Both RPE65 and retinoschisin were detectable and demonstrated contrasting trends in diabetics with and without retinopathy.
37	18837956	In combination with rhodopsin, RPE65, and retinoschisin, mRNA may offer a useful tool in developing a blood test for DR.
38	20876139	Likewise, A2E also inhibited isomerohydrolase activity in cells coexpressing RPE65, lecithin retinol acyltransferase (LRAT), and cellular retinaldehyde-binding protein.
39	20876139	In vitro isomerohydrolase activity assays confirmed that A2E inhibited enzymatic activity of recombinant RPE65 in a concentration-dependent manner, but did not inhibit LRAT activity.
40	20876139	Likewise, A2E also inhibited isomerohydrolase activity in cells coexpressing RPE65, lecithin retinol acyltransferase (LRAT), and cellular retinaldehyde-binding protein.
41	20876139	In vitro isomerohydrolase activity assays confirmed that A2E inhibited enzymatic activity of recombinant RPE65 in a concentration-dependent manner, but did not inhibit LRAT activity.