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Gene Information
Gene symbol: RPH3AL
Gene name: rabphilin 3A-like (without C2 domains)
HGNC ID: 10296
Synonyms: Noc2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CREM | 1 hits |
| 2 | INS | 1 hits |
| 3 | MIRN96 | 1 hits |
| 4 | RAB27A | 1 hits |
| 5 | RAB3A | 1 hits |
| 6 | S1PR4 | 1 hits |
| 7 | SNAP25 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16498408 | ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis. |
| 2 | 16498408 | The GTPases Rab3a and Rab27a and their effectors Granuphilin/Slp4 and Noc2 are essential regulators of neuroendocrine secretion. |
| 3 | 16498408 | ICER overexpression diminished the level of Granuphilin, Noc2, Rab3a and Rab27a by binding to cAMP responsive elements located in the promoters of these genes and inhibited exocytosis of beta-cells in response to secretagogues. |
| 4 | 16498408 | We propose that induction of inappropriate ICER levels lead to defects in the secretory process of pancreatic beta-cells possibly contributing, in conjunction with other known deleterious effects of hyperglycemia, to defective insulin release in type 2 diabetes. |
| 5 | 16498408 | ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis. |
| 6 | 16498408 | The GTPases Rab3a and Rab27a and their effectors Granuphilin/Slp4 and Noc2 are essential regulators of neuroendocrine secretion. |
| 7 | 16498408 | ICER overexpression diminished the level of Granuphilin, Noc2, Rab3a and Rab27a by binding to cAMP responsive elements located in the promoters of these genes and inhibited exocytosis of beta-cells in response to secretagogues. |
| 8 | 16498408 | We propose that induction of inappropriate ICER levels lead to defects in the secretory process of pancreatic beta-cells possibly contributing, in conjunction with other known deleterious effects of hyperglycemia, to defective insulin release in type 2 diabetes. |
| 9 | 18177263 | Here, we show that two non-coding microRNAs, miR124a and miR96, modulate the expression of proteins involved in insulin exocytosis and affect secretion of the beta-cell line MIN6B1. miR124a increases the levels of SNAP25, Rab3A and synapsin-1A and decreases those of Rab27A and Noc2. |
| 10 | 18177263 | Over-expression of miR124a leads to exaggerated hormone release under basal conditions and a reduction in glucose-induced secretion. miR96 increases mRNA and protein levels of granuphilin, a negative modulator of insulin exocytosis, and decreases the expression of Noc2, resulting in lower capacity of MIN6B1 cells to respond to secretagogues. |
| 11 | 18177263 | Our data identify miR124a and miR96 as novel regulators of the expression of proteins playing a critical role in insulin exocytosis and in the release of other hormones and neurotransmitters. |