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Gene Information
Gene symbol: RPS6KA5
Gene name: ribosomal protein S6 kinase, 90kDa, polypeptide 5
HGNC ID: 10434
Synonyms: MSK1, RLPK
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GCG | 1 hits |
| 2 | GIP | 1 hits |
| 3 | HDAC9 | 1 hits |
| 4 | TMPRSS11D | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21818121 | Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the major incretin hormones that exert insulinotropic and anti-apoptotic actions on pancreatic β-cells. |
| 2 | 21818121 | Overexpression of Kv2.1 in INS-1 β-cells potentiated apoptosis in response to mitochondrial and ER stress and, conversely, co-stimulation with GIP/GLP-1 uncoupled this potentiation, suppressing apoptosis. |
| 3 | 21818121 | In parallel, incretins promoted phosphorylation and acetylation of Kv2.1 via pathways involving protein kinase A (PKA)/mitogen- and stress-activated kinase-1 (MSK-1) and histone acetyltransferase (HAT)/histone deacetylase (HDAC). |
| 4 | 21818121 | Further studies demonstrated that acetylation of Kv2.1 was mediated by incretin actions on nuclear/cytoplasmic shuttling of CREB binding protein (CBP) and its interaction with Kv2.1. |
| 5 | 21818121 | Regulation of β-cell survival by GIP and GLP-1 therefore involves post-translational modifications (PTMs) of Kv channels by PKA/MSK-1 and HAT/HDAC. |