Ignet

Gene Information

Gene symbol: S1PR3

Gene name: sphingosine-1-phosphate receptor 3

HGNC ID: 3167

Synonyms: EDG-3

Related Genes

#	Gene Symbol	Number of hits
1	APOE	1 hits
2	CCBP2	1 hits
3	CCK	1 hits
4	CD55	1 hits
5	CXCR7	1 hits
6	LGALS1	1 hits
7	MBTPS1	1 hits
8	ORAI1	1 hits
9	PLA2G7	1 hits
10	PRF1	1 hits
11	RGS13	1 hits
12	S1PR1	1 hits
13	S1PR2	1 hits
14	SPN	1 hits
15	STIM1	1 hits
16	TLR3	1 hits
17	ZNF395	1 hits

Related Sentences

#	PMID	Sentence
1	12882914	EDG-1 mRNA but not EDG-3 mRNA was rapidly induced relative to 18S rRNA after stimulation of isolated islets with phorbol 12-myristate 13-acetate (PMA) or cholecystokinin-8S for 2 h.
2	12882914	The protein kinase C inhibitor GF 109203X blocked the EDG-1 induction by PMA.
3	12882914	Stimulation of EDG receptors in islets and INS-1 cells with SPP inhibited glucagon-like peptide 1 (GLP-1)-stimulated cAMP production and insulin secretion in a concentration-dependent manner.
4	12882914	Thus, EDG receptors are expressed in pancreatic islet beta-cells and G(i) seems to mediate the inhibition by SPP of adenylyl cyclase and cAMP formation and inhibition of the stimulation of insulin secretion by GLP-1.
5	16234413	In endothelial cells, S1P has been shown to modulate the activity of the endothelial nitric-oxide synthase (eNOS) through phosphorylation operated by Akt.
6	16234413	Nitric oxide (NO) produced by neuronal nitric-oxide synthase and eNOS plays a central role in triggering and maintaining penile erection.
7	16234413	This study has assessed the possibility of a similar cross-talk between eNOS and S1P in human corpus cavernosum and whether this interaction is connected to penile vascular response.
8	16234413	Quantitative reverse transcription-polymerase chain reaction demonstrated the presence of S1P(1), S1P(2), and S1P(3) receptors in both the human corpus cavernosum (HCC) and the penile artery.
9	16234413	In human tissue, S1P seems to be the possible candidate for the activation of the eNOS calcium-independent pathway.
10	16960101	We found expression of S1P1, S1P2, and S1P3 receptors on NOD aortic endothelial cells.
11	18424450	Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.
12	18424450	A similar result of milder disease course and reduced astroglial proliferation was obtained by deletion of the gene for the S1P(3) receptor, a G protein-coupled receptor enriched in astrocytes.
13	18424450	Because astrocyte responses are involved in many types of neurodegeneration, the Sphk1/S1P receptor signaling axis may be generally important during the pathogenesis of neurodegenerative diseases.
14	21270296	SOCE was observed in VSMCs lacking either S1P(2) or S1P(3) receptors, suggesting that S1P acts via multiple signaling pathways.
15	21270296	Finally, S1P-induced SOCE was larger in proliferative than in contractile VSMCs, correlating with increases in STIM1, Orai1, S1P(1), and S1P(3) receptor mRNA.
16	21270296	SOCE was observed in VSMCs lacking either S1P(2) or S1P(3) receptors, suggesting that S1P acts via multiple signaling pathways.
17	21270296	Finally, S1P-induced SOCE was larger in proliferative than in contractile VSMCs, correlating with increases in STIM1, Orai1, S1P(1), and S1P(3) receptor mRNA.
18	22595806	S1P1 and S1P3 are potential markers of cardiac microangiopathy in diabetes.
19	23740954	Differentiation of B cells into the MZ subset is governed by BCR signal strength and specificity, NF-κB activation through the B cell-activating factor belonging to the TNF family (BAFF) receptor, Notch2 signaling, and migration signals mediated by chemokine, integrin, and sphingosine-1-phosphate receptors.
20	23740954	Analysis of microarray expression data indicated that NOD MZ and precursor transitional 2-MZ subsets were particularly dysregulated for genes controlling cellular trafficking, including Apoe, Ccbp2, Cxcr7, Lgals1, Pla2g7, Rgs13, S1pr3, Spn, Bid, Cd55, Prf1, and Tlr3.