Ignet

Gene Information

Gene symbol: S1PR4

Gene name: sphingosine-1-phosphate receptor 4

HGNC ID: 3170

Related Genes

#	Gene Symbol	Number of hits
1	MBTPS1	1 hits
2	RAB27A	1 hits
3	RAB3A	1 hits
4	RPH3AL	1 hits

Related Sentences

#	PMID	Sentence
1	12270137	Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.
2	12270137	The S1P(4) receptor has generated interest due to its lymphoid tissue distribution.
3	12270137	While the S1P(4) receptor binds the prototypical ligand, S1P, a survey of other lysosphingolipids demonstrated that 4D-hydroxysphinganine 1-phosphate, more commonly known as phytosphingosine 1-phosphate (PhS1P), binds to S1P(4) with higher affinity.
4	12270137	Using radiolabeled S1P (S133P), the affinity of PhS1P for the S1P(4) receptor is 1.6nM, while that of S1P is nearly 50-fold lower (119+/-20nM).
5	12270137	The present study demonstrates the utility of a novel radiolabeled probe, PhS133P, for in vitro studies of the S1P(4) receptor pharmacology.
6	12270137	Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.
7	12270137	The S1P(4) receptor has generated interest due to its lymphoid tissue distribution.
8	12270137	While the S1P(4) receptor binds the prototypical ligand, S1P, a survey of other lysosphingolipids demonstrated that 4D-hydroxysphinganine 1-phosphate, more commonly known as phytosphingosine 1-phosphate (PhS1P), binds to S1P(4) with higher affinity.
9	12270137	Using radiolabeled S1P (S133P), the affinity of PhS1P for the S1P(4) receptor is 1.6nM, while that of S1P is nearly 50-fold lower (119+/-20nM).
10	12270137	The present study demonstrates the utility of a novel radiolabeled probe, PhS133P, for in vitro studies of the S1P(4) receptor pharmacology.
11	12270137	Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.
12	12270137	The S1P(4) receptor has generated interest due to its lymphoid tissue distribution.
13	12270137	While the S1P(4) receptor binds the prototypical ligand, S1P, a survey of other lysosphingolipids demonstrated that 4D-hydroxysphinganine 1-phosphate, more commonly known as phytosphingosine 1-phosphate (PhS1P), binds to S1P(4) with higher affinity.
14	12270137	Using radiolabeled S1P (S133P), the affinity of PhS1P for the S1P(4) receptor is 1.6nM, while that of S1P is nearly 50-fold lower (119+/-20nM).
15	12270137	The present study demonstrates the utility of a novel radiolabeled probe, PhS133P, for in vitro studies of the S1P(4) receptor pharmacology.
16	12270137	Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.
17	12270137	The S1P(4) receptor has generated interest due to its lymphoid tissue distribution.
18	12270137	While the S1P(4) receptor binds the prototypical ligand, S1P, a survey of other lysosphingolipids demonstrated that 4D-hydroxysphinganine 1-phosphate, more commonly known as phytosphingosine 1-phosphate (PhS1P), binds to S1P(4) with higher affinity.
19	12270137	Using radiolabeled S1P (S133P), the affinity of PhS1P for the S1P(4) receptor is 1.6nM, while that of S1P is nearly 50-fold lower (119+/-20nM).
20	12270137	The present study demonstrates the utility of a novel radiolabeled probe, PhS133P, for in vitro studies of the S1P(4) receptor pharmacology.
21	12270137	Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.
22	12270137	The S1P(4) receptor has generated interest due to its lymphoid tissue distribution.
23	12270137	While the S1P(4) receptor binds the prototypical ligand, S1P, a survey of other lysosphingolipids demonstrated that 4D-hydroxysphinganine 1-phosphate, more commonly known as phytosphingosine 1-phosphate (PhS1P), binds to S1P(4) with higher affinity.
24	12270137	Using radiolabeled S1P (S133P), the affinity of PhS1P for the S1P(4) receptor is 1.6nM, while that of S1P is nearly 50-fold lower (119+/-20nM).
25	12270137	The present study demonstrates the utility of a novel radiolabeled probe, PhS133P, for in vitro studies of the S1P(4) receptor pharmacology.
26	16498408	ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis.
27	16498408	The GTPases Rab3a and Rab27a and their effectors Granuphilin/Slp4 and Noc2 are essential regulators of neuroendocrine secretion.
28	16498408	ICER overexpression diminished the level of Granuphilin, Noc2, Rab3a and Rab27a by binding to cAMP responsive elements located in the promoters of these genes and inhibited exocytosis of beta-cells in response to secretagogues.
29	16498408	We propose that induction of inappropriate ICER levels lead to defects in the secretory process of pancreatic beta-cells possibly contributing, in conjunction with other known deleterious effects of hyperglycemia, to defective insulin release in type 2 diabetes.