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Gene Information
Gene symbol: SCAP
Gene name: SREBF chaperone
HGNC ID: 30634
Synonyms: KIAA0199
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CNBP | 1 hits |
| 2 | CTCFL | 1 hits |
| 3 | EGFR | 1 hits |
| 4 | HMG1L1 | 1 hits |
| 5 | INSIG1 | 1 hits |
| 6 | INSIG2 | 1 hits |
| 7 | PIK3CA | 1 hits |
| 8 | PLXNA4 | 1 hits |
| 9 | RHOA | 1 hits |
| 10 | SREBF1 | 1 hits |
| 11 | SREBF2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12869692 | Insulin-induced gene 1 (insig-1) mRNA rose progressively with a high-fat diet and declined on a restricted diet. |
| 2 | 12869692 | Because insig-1 binds sterol regulatory element-binding protein cleavage-activating protein in the endoplasmic reticulum, thereby blocking proteolytic processing required for sterol regulatory element-binding protein activation, we tested its influence on lipogenesis. |
| 3 | 12869692 | In differentiating 3T3-L1 cells, insig-1 and -2 rose in parallel with aP2 mRNA during differentiation. |
| 4 | 12869692 | Transfection of mouse or human insig-1 into 3T3-L1 preadipocytes completely prevented oil red O staining and blocked upregulation of aP2, peroxisome proliferator-activated receptor gamma2, and carbohydrate response element-binding protein, while reducing down-regulation of preadipocyte factor 1. |
| 5 | 18195716 | Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? |
| 6 | 18195716 | We therefore hypothesized that the major genes involved in the SREBP activation of fatty acids and cholesterol production (SREBF1, SREBF2, SCAP, INSIG1 and INSIG2) would be strong candidate genes for interindividual variation in drug-induced weight gain. |
| 7 | 22031849 | Site 1 protease was required, since its inhibition by AEBSF prevented SREBP-1 activation. |
| 8 | 22031849 | SCAP, the ER-associated chaperone for SREBP-1, was also necessary since its inhibitor fatostatin also blocked SREBP-1 activation. |
| 9 | 22031849 | Signaling through the EGFR/phosphatidylinositol 3-kinase (PI3K) pathway, which we previously showed mediates HG-induced TGF-β1 upregulation, and through RhoA, were upstream of SREBP-1 activation (Wu D, Peng F, Zhang B, Ingram AJ, Gao B, Krepinsky JC. |
| 10 | 22031849 | Thus HG-induced SREBP-1 activation requires EGFR/PI3K/RhoA signaling and SCAP-mediated transport to the Golgi for its proteolytic cleavage. |
| 11 | 22031849 | Site 1 protease was required, since its inhibition by AEBSF prevented SREBP-1 activation. |
| 12 | 22031849 | SCAP, the ER-associated chaperone for SREBP-1, was also necessary since its inhibitor fatostatin also blocked SREBP-1 activation. |
| 13 | 22031849 | Signaling through the EGFR/phosphatidylinositol 3-kinase (PI3K) pathway, which we previously showed mediates HG-induced TGF-β1 upregulation, and through RhoA, were upstream of SREBP-1 activation (Wu D, Peng F, Zhang B, Ingram AJ, Gao B, Krepinsky JC. |
| 14 | 22031849 | Thus HG-induced SREBP-1 activation requires EGFR/PI3K/RhoA signaling and SCAP-mediated transport to the Golgi for its proteolytic cleavage. |
| 15 | 23300278 | In combined South Asian meta-analysis, we observed six suggestive associations (P < 10⁻⁵ to < 10⁻⁷), including SNPs at HMG1L1/CTCFL, PLXNA4, SCAP, and chr5p11. |
| 16 | 23585733 | The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. |