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Gene Information
Gene symbol: SCYL1
Gene name: SCY1-like 1 (S. cerevisiae)
HGNC ID: 14372
Synonyms: HT019, P105, GKLP, NKTL, TAPK, TRAP, TEIF, MGC78454
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD40 | 1 hits |
| 2 | FKBP4 | 1 hits |
| 3 | GORASP1 | 1 hits |
| 4 | RELB | 1 hits |
| 5 | RPS3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19706790 | We detected expression of p65, Rel-B, p50, p105, p52, and the ribosomal protein S3 (rpS3) in human islet cells. |
| 2 | 19706790 | Among these, only p65 and rpS3 were translocated from the cytosolic to the nuclear fraction in response to cytokines. |
| 3 | 19706790 | This resulted in increased expression of c-Rel and inhibitory factor κB, increased κB-binding activity, and augmented protein levels of Bcl-X(L,) c-IAP2, and heat shock protein 72. c-Rel expression in human islet cells protected against cytokine-induced caspase 3 activation and cell death. c-Rel protected also against streptozotocin- and H(2)O(2)-induced cell death, in both intact rat islets and human islet cells. |
| 4 | 19706790 | We conclude that rpS3 participates in NF-κB signaling and that a genetic increase in the activity of the NF-κB subunit c-Rel results in protection against cell death in human islets. |