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Gene Information

Gene symbol: SDHC

Gene name: succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa

HGNC ID: 10682

Related Genes

#	Gene Symbol	Number of hits
1	IGFALS	1 hits
2	NF1	1 hits
3	RET	1 hits
4	SDHB	1 hits
5	SDHD	1 hits
6	VHL	1 hits

Related Sentences

#	PMID	Sentence
1	9605930	Binding of STAT5a and STAT5b to a single element resembling a gamma-interferon-activated sequence mediates the growth hormone induction of the mouse acid-labile subunit promoter in liver cells.
2	9605930	After birth, the endocrine actions of insulin-like growth factor (IGF)-I and -II become increasingly important.
3	9605930	In postnatal animals, most of circulating IGFs occur in 150-kDa complexes formed by association of an acid-labile subunit (ALS) with complexes of IGF and IGF-binding protein-3.
4	9605930	To map the GH response element, a series of 5'-deletion fragments of the mouse ALS promoter (nt -2001 to -49, A(+1)TG) were inserted in the luciferase reporter plasmid pGL3 and transfected into the H4-II-E rat hepatoma cell line.
5	9605930	Using antibodies directed against members of the family of signal transducers and activators of transcription (STAT), this complex was shown to be composed of STAT5a and STAT5b.
6	9605930	Thus, the transcriptional activation of the mouse ALS gene by GH is mediated by the binding of STAT5 isoforms to a single GAS-like element.
7	17427103	The genes currently known to be responsible for tumor formation are RET, VHL, NF1, SDHB, SDHC and SDHD.
8	17427103	Germline mutations of these genes increase the risk of developing pheochromocytomas and/or paragangliomas which variably associate with other neoplasms and characterize diverse clinical syndromes such as MEN 2, von Hippel-Lindau (VHL), and neurofibromatosis type 1 (NF 1), or the PGL syndromes, respectively.