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Gene Information
Gene symbol: SDHD
Gene name: succinate dehydrogenase complex, subunit D, integral membrane protein
HGNC ID: 10683
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXA2 | 1 hits |
| 2 | HNF1A | 1 hits |
| 3 | HNF1B | 1 hits |
| 4 | NF1 | 1 hits |
| 5 | RET | 1 hits |
| 6 | SDHB | 1 hits |
| 7 | SDHC | 1 hits |
| 8 | SLC2A2 | 1 hits |
| 9 | VHL | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10748140 | DNase I footprinting and electrophoretic mobility shift assay indicated that site C contained one binding site for hepatocyte nuclear factor 1 (HNF1) and two binding sites for HNF3. |
| 2 | 10748140 | The mutations at positions +101 and +103, which are considered to be critical in binding HNF1 and HNF3, resulted in a 53% decrease in promoter activity, whereas the mutation of the proximal HNF3 binding site (+115 and +117) reduced promoter activity by 28%. |
| 3 | 10748140 | The mutations of these four sites resulted in marked decrease (70%) in promoter activity as well as diminished bindings of HNF1 and HNF3. |
| 4 | 10748140 | A to G mutation, which causes conversion of the HNF1 and HNF3 binding sequence to the NF-Y binding site, resulted in a 22% decrease in promoter activity. |
| 5 | 10748140 | We identified that both HNF1 and HNF3 function as transcriptional activators in GLUT2 gene expression. |
| 6 | 10748140 | Coexpression of the pGL+74 (+74 to +301) construct with the HNF1alpha and HNF3beta expression vectors in NIH 3T3 cells showed the synergistic effect on GLUT2 promoter activity compared with the expression of HNF1alpha, HNF3beta, or a combination of HNF1beta and HNF3beta. |
| 7 | 10748140 | These data suggest that HNF1alpha and HNF3beta may be the most important players in the tissue-specific expression of the human GLUT2 gene. |
| 8 | 17427103 | The genes currently known to be responsible for tumor formation are RET, VHL, NF1, SDHB, SDHC and SDHD. |
| 9 | 17427103 | Germline mutations of these genes increase the risk of developing pheochromocytomas and/or paragangliomas which variably associate with other neoplasms and characterize diverse clinical syndromes such as MEN 2, von Hippel-Lindau (VHL), and neurofibromatosis type 1 (NF 1), or the PGL syndromes, respectively. |
| 10 | 17427103 | The genes currently known to be responsible for tumor formation are RET, VHL, NF1, SDHB, SDHC and SDHD. |
| 11 | 17427103 | Germline mutations of these genes increase the risk of developing pheochromocytomas and/or paragangliomas which variably associate with other neoplasms and characterize diverse clinical syndromes such as MEN 2, von Hippel-Lindau (VHL), and neurofibromatosis type 1 (NF 1), or the PGL syndromes, respectively. |