Ignet

Gene Information

Gene symbol: SEC14L2

Gene name: SEC14-like 2 (S. cerevisiae)

HGNC ID: 10699

Synonyms: TAP, SPF, KIAA1186, KIAA1658

Related Genes

#	Gene Symbol	Number of hits
1	CD8A	1 hits
2	HLA-A	1 hits
3	HLA-DRB1	1 hits
4	IDDM2	1 hits
5	INS	1 hits
6	PSMB8	1 hits
7	PSMB9	1 hits
8	TAP2	1 hits
9	TNFRSF10A	1 hits

Related Sentences

#	PMID	Sentence
1	7558930	TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.
2	7558930	While present evidence implicates HLA-DQ as the major susceptibility locus in IDDM, as class I expression apparently plays a role in the progression of disease, the possibility exists that the association attributed to HLA-DQ is in fact due to an association with the TAP genes.
3	7558930	Several studies have concluded that the alleles of TAP1 are not significantly associated with IDDM; this report concentrates on the more telomeric TAP2 locus.
4	7558930	Overall, our results indicate only a modest association of IDDM with TAP2; however, the newly described TAP2*F allele was found to be significantly increased in a modest subset of our large diabetic population.
5	7558930	These data, generated from the same population of controls and diabetics we previously studied at all other relevant MHC loci, provide additional evidence that the HLA susceptibility to IDDM maps to HLA-DQ.
6	7558930	TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.
7	7558930	While present evidence implicates HLA-DQ as the major susceptibility locus in IDDM, as class I expression apparently plays a role in the progression of disease, the possibility exists that the association attributed to HLA-DQ is in fact due to an association with the TAP genes.
8	7558930	Several studies have concluded that the alleles of TAP1 are not significantly associated with IDDM; this report concentrates on the more telomeric TAP2 locus.
9	7558930	Overall, our results indicate only a modest association of IDDM with TAP2; however, the newly described TAP2*F allele was found to be significantly increased in a modest subset of our large diabetic population.
10	7558930	These data, generated from the same population of controls and diabetics we previously studied at all other relevant MHC loci, provide additional evidence that the HLA susceptibility to IDDM maps to HLA-DQ.
11	7871524	Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.
12	7871524	Although many studies have established an association between insulin-dependent diabetes mellitus (IDDM) and the class II region of the human major histocompatibility complex (MHC), it has been difficult to assign susceptibility to a single locus.
13	7871524	Recently, two antigen-processing genes, TAP1 and TAP2, have been identified within the region.
14	7871524	To further investigate this question, we have characterized TAP1 and TAP2 alleles in 129 IDDM patients from Sardinia, a population with limited genetic heterogeneity and a high disease incidence.
15	7871524	Further analysis suggested that TAP2C was in LD with HLA-DRB11401 and subtypes of HLA-DRB111, alleles which were not observed in the IDDM population.
16	7871524	Our data supports the conclusion that there is no primary association between TAP2 alleles and IDDM, and that previously reported associations may be due to LD with other class II loci.
17	7871524	Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.
18	7871524	Although many studies have established an association between insulin-dependent diabetes mellitus (IDDM) and the class II region of the human major histocompatibility complex (MHC), it has been difficult to assign susceptibility to a single locus.
19	7871524	Recently, two antigen-processing genes, TAP1 and TAP2, have been identified within the region.
20	7871524	To further investigate this question, we have characterized TAP1 and TAP2 alleles in 129 IDDM patients from Sardinia, a population with limited genetic heterogeneity and a high disease incidence.
21	7871524	Further analysis suggested that TAP2C was in LD with HLA-DRB11401 and subtypes of HLA-DRB111, alleles which were not observed in the IDDM population.
22	7871524	Our data supports the conclusion that there is no primary association between TAP2 alleles and IDDM, and that previously reported associations may be due to LD with other class II loci.
23	7871524	Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.
24	7871524	Although many studies have established an association between insulin-dependent diabetes mellitus (IDDM) and the class II region of the human major histocompatibility complex (MHC), it has been difficult to assign susceptibility to a single locus.
25	7871524	Recently, two antigen-processing genes, TAP1 and TAP2, have been identified within the region.
26	7871524	To further investigate this question, we have characterized TAP1 and TAP2 alleles in 129 IDDM patients from Sardinia, a population with limited genetic heterogeneity and a high disease incidence.
27	7871524	Further analysis suggested that TAP2C was in LD with HLA-DRB11401 and subtypes of HLA-DRB111, alleles which were not observed in the IDDM population.
28	7871524	Our data supports the conclusion that there is no primary association between TAP2 alleles and IDDM, and that previously reported associations may be due to LD with other class II loci.
29	8157258	Stable cell surface presentation of MHC class I molecules requires active transport of antigenic peptides across the endoplasmic reticulum by products of two genes, TAP1 and TAP2, which are maped in the MHC class II region.
30	8157258	The data suggests that the association of TAP2 allele with IDDM disease may be a simple reflection of the linkage disequilibrium between TAP allele and DR4 gene.
31	8157258	Stable cell surface presentation of MHC class I molecules requires active transport of antigenic peptides across the endoplasmic reticulum by products of two genes, TAP1 and TAP2, which are maped in the MHC class II region.
32	8157258	The data suggests that the association of TAP2 allele with IDDM disease may be a simple reflection of the linkage disequilibrium between TAP allele and DR4 gene.
33	8847232	Absence of TAP2 contribution to association with insulin-dependent diabetes mellitus.
34	8847232	The polymorphic TAP1 and TAP2 genes encode a transporter protein required for delivery of cytosolic peptides to class I molecules in the endoplasmic reticulum.
35	8847232	Associations have been observed between TAP2 alleles and predisposition to autoimmune diseases such as IDDM but their interpretation has been complicated by the existence of LD between TAP2 and HLA class II loci, and conclusions are still contradictory.
36	8847232	We then addressed the question of whether TAP2 is an independent additional IDDM-protective or predisposing genetic factor.
37	8847232	A decreased TAP2-B phenotype frequency was observed in DRB103- and DRB104-negative IDDM patients compared with DRB103- and DRB104-negative normal controls (38.6% vs 63%, pc < 0.05), but was probably related to a combination of different weak LD between DRB1 and TAP2 alleles.
38	8847232	It thus appears that there is no primary association between TAP2 alleles and IDDM.
39	8988536	Genetic heterogeneity between type 1a and type 1b insulin-dependent diabetes mellitus: HLA class II and TAP gene analysis.
40	8988536	HLA genes DRB1, DQA1 and DQB1 were studied at the genomic level, as well as genes TAP1 and TAP2.
41	8988536	Genetic heterogeneity between type 1a and type 1b insulin-dependent diabetes mellitus: HLA class II and TAP gene analysis.
42	8988536	HLA genes DRB1, DQA1 and DQB1 were studied at the genomic level, as well as genes TAP1 and TAP2.
43	9226129	Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.
44	9226129	Type 1 diabetes mellitus (IDDM) is an autoimmune disorder in which the alleles HLA DQA10501-DQB10201 and DQA10301-DQB10302 confer strong susceptibility.
45	9226129	The genes for transporters associated with antigen processing (TAP1 and TAP2) are located near HLA DQ and display only a limited degree of polymorphism.
46	9226129	Since polymorphisms of TAP might influence susceptibility to IDDM possibly by selection of different antigen peptides, we investigated sequence variants of TAP1 and TAP2 genes in 120 German patients with IDDM and 218 random healthy German controls by polymerase chain reaction (PCR) followed by sequence-specific oligonucleotide analysis (SSO), single-strand conformation polymorphism (SSCP) analysis and amplification refractory mutation system (ARMS).
47	9226129	In conclusion, our findings indicate that the observed association of TAP variants with IDDM in German patients is due to linkage disequilibrium with HLA DQ alleles/DRB1*04 subtypes.
48	9226129	Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.
49	9226129	Type 1 diabetes mellitus (IDDM) is an autoimmune disorder in which the alleles HLA DQA10501-DQB10201 and DQA10301-DQB10302 confer strong susceptibility.
50	9226129	The genes for transporters associated with antigen processing (TAP1 and TAP2) are located near HLA DQ and display only a limited degree of polymorphism.
51	9226129	Since polymorphisms of TAP might influence susceptibility to IDDM possibly by selection of different antigen peptides, we investigated sequence variants of TAP1 and TAP2 genes in 120 German patients with IDDM and 218 random healthy German controls by polymerase chain reaction (PCR) followed by sequence-specific oligonucleotide analysis (SSO), single-strand conformation polymorphism (SSCP) analysis and amplification refractory mutation system (ARMS).
52	9226129	In conclusion, our findings indicate that the observed association of TAP variants with IDDM in German patients is due to linkage disequilibrium with HLA DQ alleles/DRB1*04 subtypes.
53	9226129	Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.
54	9226129	Type 1 diabetes mellitus (IDDM) is an autoimmune disorder in which the alleles HLA DQA10501-DQB10201 and DQA10301-DQB10302 confer strong susceptibility.
55	9226129	The genes for transporters associated with antigen processing (TAP1 and TAP2) are located near HLA DQ and display only a limited degree of polymorphism.
56	9226129	Since polymorphisms of TAP might influence susceptibility to IDDM possibly by selection of different antigen peptides, we investigated sequence variants of TAP1 and TAP2 genes in 120 German patients with IDDM and 218 random healthy German controls by polymerase chain reaction (PCR) followed by sequence-specific oligonucleotide analysis (SSO), single-strand conformation polymorphism (SSCP) analysis and amplification refractory mutation system (ARMS).
57	9226129	In conclusion, our findings indicate that the observed association of TAP variants with IDDM in German patients is due to linkage disequilibrium with HLA DQ alleles/DRB1*04 subtypes.
58	9226129	Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.
59	9226129	Type 1 diabetes mellitus (IDDM) is an autoimmune disorder in which the alleles HLA DQA10501-DQB10201 and DQA10301-DQB10302 confer strong susceptibility.
60	9226129	The genes for transporters associated with antigen processing (TAP1 and TAP2) are located near HLA DQ and display only a limited degree of polymorphism.
61	9226129	Since polymorphisms of TAP might influence susceptibility to IDDM possibly by selection of different antigen peptides, we investigated sequence variants of TAP1 and TAP2 genes in 120 German patients with IDDM and 218 random healthy German controls by polymerase chain reaction (PCR) followed by sequence-specific oligonucleotide analysis (SSO), single-strand conformation polymorphism (SSCP) analysis and amplification refractory mutation system (ARMS).
62	9226129	In conclusion, our findings indicate that the observed association of TAP variants with IDDM in German patients is due to linkage disequilibrium with HLA DQ alleles/DRB1*04 subtypes.
63	17491658	Peptides are assembled with class I molecules by pathways that are either dependent or independent of transport by ABC proteins (TAP) and degradation in the immunoproteasome by its subunits LMP2 and LMP7.
64	17491658	Therefore, allelic variations in the coding sequences of TAP and LMP were suspected for a long time to be responsible for improper antigen processing, interruption of self-peptide presentation and reduced cell surface expression of MHC class I molecules resulting in the activation of autoreactive CD8(+) T cells.
65	17491658	Peptides are assembled with class I molecules by pathways that are either dependent or independent of transport by ABC proteins (TAP) and degradation in the immunoproteasome by its subunits LMP2 and LMP7.
66	17491658	Therefore, allelic variations in the coding sequences of TAP and LMP were suspected for a long time to be responsible for improper antigen processing, interruption of self-peptide presentation and reduced cell surface expression of MHC class I molecules resulting in the activation of autoreactive CD8(+) T cells.