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Gene Information
Gene symbol: SERPINA3
Gene name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
HGNC ID: 16
Synonyms: ACT, alpha-1-antichymotrypsin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADRA1D | 1 hits |
| 2 | APOE | 1 hits |
| 3 | BCHE | 1 hits |
| 4 | CP | 1 hits |
| 5 | ENO2 | 1 hits |
| 6 | HNF4A | 1 hits |
| 7 | IGFBP1 | 1 hits |
| 8 | LPAL2 | 1 hits |
| 9 | PLG | 1 hits |
| 10 | PSEN1 | 1 hits |
| 11 | S100A1 | 1 hits |
| 12 | SERPINA1 | 1 hits |
| 13 | SERPINA7 | 1 hits |
| 14 | TF | 1 hits |
| 15 | TIMP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1323058 | Effects of interleukin-6 on the expression of thyroid hormone-binding protein genes in cultured human hepatoblastoma-derived (Hep G2) cells. |
| 2 | 1323058 | T4-binding globulin (TBG) shares a high degree of homology with two serpin antiproteases, alpha 1-antichymotrypsin (ACT) and alpha 1-antitrypsin (AT), whose synthesis is increased during the acute phase phenomenon, which accompanies trauma, infections, and neoplasms. |
| 3 | 1323058 | When evaluated in human hepatoblastoma-derived (Hep G2) cells exposed to different doses of the recombinant human cytokine for variable time intervals, IL-6 caused a dose- and time-dependent decrease in the secretion of [35S]methionine-labeled TBG, transthyretin (TTR), and albumin. |
| 4 | 1323058 | IL-6 did, however, cause a decrease in the steady state levels of mRNA for TTR, TBG, and albumin and an increase in ACT and AT mRNAs. |
| 5 | 1323058 | In addition, nuclear run-off assay demonstrated a decrease in the transcription of TTR, TBG, and albumin genes and an increased transcription of the ACT gene. |
| 6 | 1323058 | Quantitation of the results showed that changes in the secretion of proteins, in steady state mRNA levels, and in gene transcription were superimposable for each protein, indicating that IL-6 exerts its effect on thyroid hormone-binding proteins mostly at the transcriptional level and that TTR is the thyroid hormone-binding protein showing the most pronounced negative regulation by IL-6. |
| 7 | 1323058 | The opposite effect of IL-6 on TBG and the antiproteases, despite their structural homology, underscores gene divergence among these proteins. |
| 8 | 1721940 | Compared to an age matched non diabetic control group spontaneous platelet aggregation was enhanced, plasma levels for factor VIII C, von Willebrand factor, antithrombin III and C-1-inactivator were elevated, alpha-2-macroglobulin was decreased at onset of the disease. |
| 9 | 1721940 | In comparison to the controls no significant alterations were found for ristocetin cofactor, fibrinogen, plasminogen and alpha-1-antichymotrypsin. |
| 10 | 8543320 | Immunohistochemical study of the foamy cells in the lesion showed positive reaction to anti-Kp-1, anti-S-100 alpha, beta, anti-neuron-specific enolase (NSE), anti-alpha-1-antichymotrypsin, anti-alpha-1-antitrypsin, and anti-lysozyme antibodies. |
| 11 | 10905494 | Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels. |
| 12 | 10905494 | Heterozygous mutations in the HNF-4alpha gene are responsible for maturity-onset diabetes of the young 1 (MODY1), which is characterized by pancreatic beta-cell-deficient insulin secretion. |
| 13 | 10905494 | In this study, we have identified HNF-4alpha target genes that are mainly expressed in the liver, including alpha1-antitrypsin, alpha1-antichymotrypsin, alpha-fetal protein, ceruloplasmin, IGF binding protein 1, transferrin, apolipoprotein(AI) [apo(AI)], apo(AII), apo(B), and apo(CIII). |
| 14 | 11428080 | Immunohistochemistry demonstrated positive reactions to protein S-100 and alpha-1-Antichymotrypsin, while CD 1 a-antigen and PNA were negative. |
| 15 | 12480732 | Associations of genetic polymorphisms with CAA have been investigated for genes of apolipoprotein E (APOE), presenilin 1 (PS1), alpha1-antichymotrypsin (ACT), butyrylcholinesterase, alpha2-macroglobulin, and paraoxonase. |
| 16 | 14683430 | Mammalian internal proteinase inhibitors such as cystatins, a1-antichymotrypsin, and tissue inhibitor of metalloproteinases (TIMPs) have little or no effects on the proteolytic activities of these enzymes, suggesting the evasion of the bacterium from host defense mechanisms. |
| 17 | 18408372 | Alpha-1 antichymotrypsin gene signal peptide a/t polymorphism and primary intracerebral hemorrhage. |