Ignet

Gene Information

Gene symbol: SH3D19

Gene name: SH3 domain containing 19

HGNC ID: 30418

Synonyms: DKFZp434D0215, EVE1, EBP, Kryn, SH3P19

Related Genes

#	Gene Symbol	Number of hits
1	AHR	1 hits
2	ATF3	1 hits
3	ATF6	1 hits
4	BMP7	1 hits
5	CEBPA	1 hits
6	CREB1	1 hits
7	DDIT3	1 hits
8	HSPA5	1 hits
9	MAPK1	1 hits
10	MAPK10	1 hits
11	MAPK14	1 hits
12	PPARG	1 hits
13	PPARGC1A	1 hits
14	PRDM16	1 hits
15	PTGS2	1 hits
16	RHOD	1 hits
17	UCP1	1 hits
18	XBPP1	1 hits

Related Sentences

#	PMID	Sentence
1	15213229	We identified three sites that were essential for basal COX-2 promoter activity: 1) CCAAT/enhancer-binding protein (C/EBP), 2) aryl hydrocarbon receptor (AhR), and 3) cAMP response element-binding protein (CREB).
2	15213229	Double mutation of the AhR and CREB-binding sites showed synergy in repressing COX-2 promoter activity as did mutation of all three sites.
3	15213229	We demonstrated that the transcription factors from RINm5F nuclear extracts specifically bound to oligonucleotides containing C/EBP, AhR, or CREB consensus sites.
4	15213229	Forskolin, an activator of adenyl cyclase, increased COX-2 promoter activity via the CREB site.
5	15213229	COX-2 promoter activity was also increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin, an AhR activator, through the AhR site.
6	15213229	We identified three sites that were essential for basal COX-2 promoter activity: 1) CCAAT/enhancer-binding protein (C/EBP), 2) aryl hydrocarbon receptor (AhR), and 3) cAMP response element-binding protein (CREB).
7	15213229	Double mutation of the AhR and CREB-binding sites showed synergy in repressing COX-2 promoter activity as did mutation of all three sites.
8	15213229	We demonstrated that the transcription factors from RINm5F nuclear extracts specifically bound to oligonucleotides containing C/EBP, AhR, or CREB consensus sites.
9	15213229	Forskolin, an activator of adenyl cyclase, increased COX-2 promoter activity via the CREB site.
10	15213229	COX-2 promoter activity was also increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin, an AhR activator, through the AhR site.
11	18719589	Here we demonstrate that whereas some members of the family of bone morphogenetic proteins (BMPs) support white adipocyte differentiation, BMP7 singularly promotes differentiation of brown preadipocytes even in the absence of the normally required hormonal induction cocktail.
12	18719589	BMP7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate PRDM16 (PR-domain-containing 16; ref. 4) and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha; ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (UCP1) and adipogenic transcription factors PPARgamma and CCAAT/enhancer-binding proteins (C/EBPs), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (MAP) kinase-(also known as Mapk14) and PGC-1-dependent pathways.
13	18719589	Moreover, BMP7 triggers commitment of mesenchymal progenitor cells to a brown adipocyte lineage, and implantation of these cells into nude mice results in development of adipose tissue containing mostly brown adipocytes.
14	18719589	Bmp7 knockout embryos show a marked paucity of brown fat and an almost complete absence of UCP1.
15	18719589	These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity.
16	19609006	NCB5OR is a novel flavoheme reductase with a cytochrome b5-like domain at the N-terminus and a cytochrome b5 reductase-like domain at the C terminus.
17	19609006	Ncb5or knock-out mice develop insulin deficient diabetes and loss of white adipose tissue.
18	19609006	The ER stress response was assessed by induction of BiP, ATF3, ATF6, XBP-1, and C/EBP homologous protein (CHOP).
19	19609006	In order to assess the role of ER stress in vivo, we prepared mice that lack both NCB5OR and CHOP, a proapoptotic transcription factor important in the ER stress response.
20	23646198	Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration.
21	23646198	The purpose of this study is to investigate the role of CHOP protein in T17M RHO retina.
22	23646198	Wild-type, CHOP-/-, T17M RHO and T17M RHO CHOP-/-mice were used in the study.
23	23646198	Dark-adapted ERG analysis demonstrated that by 1 month, the T17M RHO CHOP-/- mice had a 70% reduction of the a-wave amplitude compared to the T17M RHO mice.
24	23646198	The loss of function in T17M RHO CHOP-/- photoreceptors was associated with a 22-24% decline in the thickness of the outer nuclear layer.
25	23646198	These mice had significant reduction in the expression of transcription factors, Crx and Nrl, and also in mouse Rho, and human RHO.
26	23646198	In addition, the histone deacetylase 1 (Hdac1) protein was 2-fold elevated in the T17M RHO CHOP-/- retina.
27	23646198	The ablation of CHOP led to a reduction in the expression of photoreceptor-specific transcriptional factors, and both endogenous and exogenous RHO mRNA.