Ignet

Gene Information

Gene symbol: SH3YL1

Gene name: SH3 domain containing, Ysc84-like 1 (S. cerevisiae)

HGNC ID: 29546

Synonyms: Ray, DKFZP586F1318

Related Genes

#	Gene Symbol	Number of hits
1	CRK	1 hits
2	GRB2	1 hits
3	IGF1	1 hits
4	INS	1 hits
5	NCK1	1 hits

Related Sentences

#	PMID	Sentence
1	7534289	Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk.
2	7534289	Crk, a cellular homolog of v-crk, is an SH2 and SH3 domain-containing adaptor protein related to Grb2 and Nck, two proteins which have been shown to be involved in growth factor signal transduction.
3	7534289	Crk proteins have recently been found to associate with two guanine nucleotide releasing proteins, mSos and C3G, and thus appear to lie on the Ras pathway.
4	7534289	We investigated whether Crk is a target for the insulin-like growth factor I (IGF-I) receptor tyrosine kinase.
5	7534289	We show that IGF-I stimulates tyrosine phosphorylation of Crk II via stimulation of endogenous IGF-I receptors in both 293 cells and NIH-3T3 cells.
6	7534289	IGF-I stimulated tyrosine phosphorylation of Crk II in a dose- and time-dependent manner.
7	7534289	In 293 cells, which express both IGF-I and insulin receptors, insulin also induced a dose-dependent tyrosine phosphorylation of Crk II, but with somewhat reduced sensitivity, compared to IGF-I.
8	7534289	In NIH 3T3 cells, IGF-I also stimulated tyrosine phosphorylation of a 45- kDa protein which co-immunoprecipitated with Crk II.
9	7534289	These findings indicate that Crk II is an endogenous substrate of the IGF-I receptor tyrosine kinase and provide the first demonstration that a mitogenic growth factor induces tyrosine phosphorylation of endogenous c-Crk.
10	8196603	GRB-2 is a small SH2- and SH3 domain-containing adapter protein that associates with the mammalian SOS homolog to regulate p21ras during growth factor signaling.
11	8196603	During insulin stimulation, GRB-2 binds to the phosphorylated Y895VNI motif of IRS-1.
12	8196603	The myeloid progenitor cell line, 32-D, is insensitive to insulin because it contains few insulin receptors and no IRS-1.
13	8196603	Coexpression of IRS-1 or IRS-1F-895 with the insulin receptor was required for insulin-stimulated mitogenesis in 32-D cells, while expression of the insulin receptor alone was sufficient to mediate insulin-stimulated tyrosine phosphorylation of Shc and activation of p21ras and mitogen-activated protein (MAP) kinase.
14	8196603	The Shc-GRB-2 complex formed during insulin stimulation is a possible mediator of p21ras and MAP kinase activation in IRS-1-deficient 32-D cells.
15	8196603	Interestingly, IRS-1, but not IRS-1F-895, enhanced the stimulation of MAP kinase by insulin in 32-D cells expressing insulin receptors.
16	8196603	Thus, IRS-1 contributes to the stimulation of MAP kinase by insulin, probably through formation of the IRS-1-GRB-2 complex at Tyr-895.
17	8196603	Our results suggest that the Shc-GRB-2 complex and the activation of p21ras-dependent signaling pathways, including MAP kinase, are insufficient for insulin-stimulated mitogenesis and that the essential function(s) of IRS-1 in proliferative signaling is largely unrelated to IRS-1-GRB-2 complex formation.
18	8621590	Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling.
19	8621590	The Crk proto-oncogene product is an SH2 and SH3 domain-containing adaptor protein which we have previously shown to become rapidly tyrosine phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) in NIH-3T3 cells.
20	8621590	Stimulation with IGF-I resulted in a dissociation of Crk protein from IRS-1.
21	8621590	In contrast, the association of the related adaptor protein Grb2 with IRS-1 was enhanced by IGF-I stimulation.
22	8621590	In these cells, IRS-1 and 4PS both associated with Crk, and this association was also decreased by IGF-I treatment, whereas the association of Grb2 with IRS-1 and 4PS was enhanced by IGF-I.
23	8621590	These results suggest that Crk is a positive effector of IGF-I signaling, and may mediate its effects via interaction with IRS-1 and/or 4PS.
24	9480911	Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.
25	9480911	The Crk proto-oncogene product is an SH2 and SH3 domain-containing adaptor protein.
26	9480911	We have previously demonstrated that Crk-II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.
27	9480911	To determine whether this involvement includes the direct interaction of Crk-II with the cytoplasmic region of the receptor, studies were performed in vitro with glutathione S-transferase (GST) fusion proteins containing various domains of Crk-II.
28	9480911	The kinase assay in vitro showed that activated IGF-I receptors efficiently phosphorylated the GST-Crk-II fusion protein.
29	9480911	Different domains of the IGF-I receptor were expressed as (His)6-tagged fusion peptides, phosphorylated with activated wheat germ agglutinin-purified IGF-I receptors and tested for association with GST-Crk-II fusion proteins.