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Gene Information
Gene symbol: SIN3A
Gene name: SIN3 transcription regulator homolog A (yeast)
HGNC ID: 19353
Synonyms: KIAA0700, DKFZP434K2235
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HDAC1 | 1 hits |
| 2 | HDAC4 | 1 hits |
| 3 | MECP2 | 1 hits |
| 4 | NCOR1 | 1 hits |
| 5 | NCOR2 | 1 hits |
| 6 | OGT | 1 hits |
| 7 | PDX1 | 1 hits |
| 8 | RCOR1 | 1 hits |
| 9 | REST | 1 hits |
| 10 | RUNX1 | 1 hits |
| 11 | USF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10640275 | Transcriptional repression mediated by corepressors N-CoR and SMRT is a critical function of nuclear hormone receptors, and is dysregulated in human myeloid leukemias. |
| 2 | 10640275 | Surprisingly, however, numerous biochemical studies have not detected N-CoR or SMRT in mSin3- and HDAC1-containing complexes. |
| 3 | 10640275 | Here we show that these RDs are nonredundant, and that one RD, which is conserved in N-CoR and SMRT, represses transcription by interacting directly with class II HDAC4 and HDAC5. |
| 4 | 10640275 | Endogenous N-CoR and SMRT each associate with HDAC4 in a complex that does not contain mSin3A or HDAC1. |
| 5 | 16105753 | Runx1 enhances gene transcription by interacting with transcriptional coactivators such as p300 and CREB-binding protein. |
| 6 | 16105753 | However, Runx1 can also suppress gene transcription by interacting with transcriptional corepressors, including mSin3A, TLE (mammalian homolog of Groucho), and histone deacetylases. |
| 7 | 16105753 | Runx1 has been identified in leukemia-associated chromosomal translocations, including t(8;21) (Runx1-ETO/MTG8), t(16;21) (Runx1-MTG16), t(3;21) (Runx1-Evi1), t(12;21) (TEL-Runx1), and t(X;21) (Runx1-Fog2). |
| 8 | 18464933 | The fetal IUGR state was characterized by loss of USF-1 binding at the proximal promoter of Pdx1, recruitment of the histone deacetylase 1 (HDAC1) and the corepressor Sin3A, and deacetylation of histones H3 and H4. |
| 9 | 18464933 | During the neonatal period, these epigenetic changes and the reduction in Pdx1 expression could be reversed by HDAC inhibition. |
| 10 | 22371606 | Here, we show that neuronal insults trigger activation of REST and CoREST in a clinically relevant model of ischemic stroke and that REST binds a subset of "transcriptionally responsive" genes (gria2, grin1, chrnb2, nefh, nfκb2, trpv1, chrm4, and syt6), of which the AMPA receptor subunit GluA2 is a top hit. |
| 11 | 22371606 | We further show that REST assembles with CoREST, mSin3A, histone deacetylases 1 and 2, histone methyl-transferase G9a, and methyl CpG binding protein 2 at the promoters of target genes, where it orchestrates epigenetic remodeling and gene silencing. |
| 12 | 23835259 | Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart. |