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Gene Information
Gene symbol: SIPA1
Gene name: signal-induced proliferation-associated 1
HGNC ID: 10885
Synonyms: SPA1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDK6 | 1 hits |
| 2 | IL17A | 1 hits |
| 3 | MAPK11 | 1 hits |
| 4 | MAPK14 | 1 hits |
| 5 | TNF | 1 hits |
| 6 | TNFRSF6B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14634066 | Expression of CD11c, CD40, CD54, and major histocompatibility complex I-A(g7) was reduced in cells cultured with additional DcR3.Fc, compared with DCs incubated with granulocyte macrophage-colony stimulating factor and interleukin (IL)-4, indicating that DcR3 interferes with the differentiation and maturation of BM-DCs. |
| 2 | 14634066 | One of the most striking effects of DcR3.Fc on the differentiation of DCs was the up-regulation of CD86 and down-regulation of CD80, suggesting a modulatory potential to skew the T cell response toward the T helper cell type 2 (Th2) phenotype. |
| 3 | 14634066 | Moreover, the secretion of interferon-gamma from T cells cocultured with DcR3.Fc-treated DCs was profoundly suppressed, indicating that DcR3 exerts a Th1-suppressing effect on differentiating DCs. |
| 4 | 14634066 | Data from two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time-of-flight analysis show an up-regulation of some proteins-such as mitogen-activated protein kinase p38 beta, cyclin-dependent kinase 6, and signal-induced proliferation-associated gene 1-and a down-regulation of the IL-17 precursor; tumor necrosis factor-related apoptosis-inducing ligand family member-associated nuclear factor-kappaB activator-binding kinase 1; and Golgi S-nitroso-N-acetylpenicillamine in cells treated with DcR3, further demonstrating its effect on DC differentiation and function. |