Ignet

Gene Information

Gene symbol: SIRT5

Gene name: sirtuin 5

HGNC ID: 14933

Related Genes

#	Gene Symbol	Number of hits
1	CPS1	1 hits
2	SIRT1	1 hits
3	SIRT2	1 hits
4	SIRT3	1 hits
5	SIRT4	1 hits
6	SIRT6	1 hits
7	SIRT7	1 hits
8	UOX	1 hits

Related Sentences

#	PMID	Sentence
1	18054327	Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.
2	18054327	Yeast silent information regulator 2 (SIR2) is involved in extension of yeast longevity by calorie restriction, and SIRT3, SIRT4, and SIRT5 are mammalian homologs of SIR2 localized in mitochondria.
3	18054327	SIRT3, SIRT4, and SIRT5 proteins were localized in different compartments of the mitochondria.
4	18054327	When SIRT3 and SIRT5 were co-expressed in the cell, localization of SIRT3 protein changed from mitochondria to nucleus.
5	18054327	These results suggest that the SIRT3, SIRT4, and SIRT5 proteins exert distinct functions in mitochondria.
6	18054327	Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.
7	18054327	Yeast silent information regulator 2 (SIR2) is involved in extension of yeast longevity by calorie restriction, and SIRT3, SIRT4, and SIRT5 are mammalian homologs of SIR2 localized in mitochondria.
8	18054327	SIRT3, SIRT4, and SIRT5 proteins were localized in different compartments of the mitochondria.
9	18054327	When SIRT3 and SIRT5 were co-expressed in the cell, localization of SIRT3 protein changed from mitochondria to nucleus.
10	18054327	These results suggest that the SIRT3, SIRT4, and SIRT5 proteins exert distinct functions in mitochondria.
11	18054327	Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.
12	18054327	Yeast silent information regulator 2 (SIR2) is involved in extension of yeast longevity by calorie restriction, and SIRT3, SIRT4, and SIRT5 are mammalian homologs of SIR2 localized in mitochondria.
13	18054327	SIRT3, SIRT4, and SIRT5 proteins were localized in different compartments of the mitochondria.
14	18054327	When SIRT3 and SIRT5 were co-expressed in the cell, localization of SIRT3 protein changed from mitochondria to nucleus.
15	18054327	These results suggest that the SIRT3, SIRT4, and SIRT5 proteins exert distinct functions in mitochondria.
16	18054327	Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.
17	18054327	Yeast silent information regulator 2 (SIR2) is involved in extension of yeast longevity by calorie restriction, and SIRT3, SIRT4, and SIRT5 are mammalian homologs of SIR2 localized in mitochondria.
18	18054327	SIRT3, SIRT4, and SIRT5 proteins were localized in different compartments of the mitochondria.
19	18054327	When SIRT3 and SIRT5 were co-expressed in the cell, localization of SIRT3 protein changed from mitochondria to nucleus.
20	18054327	These results suggest that the SIRT3, SIRT4, and SIRT5 proteins exert distinct functions in mitochondria.
21	18054327	Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.
22	18054327	Yeast silent information regulator 2 (SIR2) is involved in extension of yeast longevity by calorie restriction, and SIRT3, SIRT4, and SIRT5 are mammalian homologs of SIR2 localized in mitochondria.
23	18054327	SIRT3, SIRT4, and SIRT5 proteins were localized in different compartments of the mitochondria.
24	18054327	When SIRT3 and SIRT5 were co-expressed in the cell, localization of SIRT3 protein changed from mitochondria to nucleus.
25	18054327	These results suggest that the SIRT3, SIRT4, and SIRT5 proteins exert distinct functions in mitochondria.
26	20097174	Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
27	20097174	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.
28	20097174	CPS1 protein was more deacetylated and activated in liver of SIRT5 Tg mice than in wild-type.
29	20097174	Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1.
30	20097174	Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
31	20097174	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.
32	20097174	CPS1 protein was more deacetylated and activated in liver of SIRT5 Tg mice than in wild-type.
33	20097174	Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1.
34	20097174	Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
35	20097174	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.
36	20097174	CPS1 protein was more deacetylated and activated in liver of SIRT5 Tg mice than in wild-type.
37	20097174	Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1.
38	20097174	Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
39	20097174	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.
40	20097174	CPS1 protein was more deacetylated and activated in liver of SIRT5 Tg mice than in wild-type.
41	20097174	Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1.
42	22249520	The nuclear sirtuins, SIRT1, SIRT6 and SIRT7, regulate the activity of key transcription factors and cofactors of numerous metabolic pathways in almost all tissues by linking nutrient signals with the cellular responses to energy demands.
43	22249520	The mitochondrial sirtuins, SIRT3, SIRT4 and SIRT5, regulate the activity of important mitochondrial enzymes and drive metabolic cycles in response to fasting and calorie restriction.
44	23085393	These results suggest that SIRT5 activates UOX through deacetylation in mouse liver mitochondria.
45	23908846	The sirtuins are highly conserved enzyme homologues of the yeast Sir2, with activities of NAD+ dependent deacetylase and/or mono ADP ribosyltransferase.
46	23908846	In addition, until recently, the role of the seven mammalian sirtuins, SIRT1 to SIRT7, in regulating lifespan was unclear.
47	24014411	Of the seven mammalian sirtuins, three localize to the mitochondria: SIRT3, SIRT4, and SIRT5.