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Gene Information
Gene symbol: SLAMF6
Gene name: SLAM family member 6
HGNC ID: 21392
Synonyms: KALI, NTBA, KALIb, Ly108, SF2000, NTB-A, CD352
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CD8A | 1 hits |
| 3 | KIR2DS2 | 1 hits |
| 4 | KLRK1 | 1 hits |
| 5 | SLAMF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17237411 | In this study, we report the production and characterization of a NOD.Nkrp1(b).Nkt1(b) congenic mouse strain, apply microarray expression analyses to limit candidate genes within the 95% confidence region, identify Slamf1 (encoding signaling lymphocyte activation molecule) and Slamf6 (encoding Ly108) as potential candidates, and demonstrate retarded signaling lymphocyte activation molecule expression during T cell development of NOD mice, resulting in reduced expression at the CD4(+)CD8(+) stage, which is consistent with decreased NKT cell production and deranged tolerance induction in NOD mice. |
| 2 | 17407193 | A role for the activating NK-receptor NKG2D has been indicated in several autoimmune diseases in humans and in animal models of type 1 diabetes and multiple sclerosis, and treatment with monoclonal antibodies to NKG2D attenuated disease severity in these models. |
| 3 | 17407193 | In an adoptive transfer-induced model of colitis, we found a significantly higher frequency of CD4(+)NKG2D(+) cells in blood, mesenteric lymph nodes, colon, and spleen from colitic mice compared to BALB/c donor-mice. |
| 4 | 17407193 | We conclude that the frequency of CD4(+)NKG2D(+) cells increase during development of experimental colitis. |