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Gene Information
Gene symbol: SLC10A1
Gene name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1
HGNC ID: 10905
Synonyms: NTCP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | SLCO1A2 | 1 hits |
| 2 | TCF7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11279518 | Tcf1-/- liver has decreased expression of the basolateral membrane bile acid transporters Slc10a1, Slc21a3 and Slc21a5, leading to impaired portal bile acid uptake and elevated plasma bile acid concentrations. |
| 2 | 11279518 | In intestine and kidneys, Tcf1-/- mice lack expression of the ileal bile acid transporter (Slc10a2), resulting in increased fecal and urinary bile acid excretion. |
| 3 | 11279518 | The Tcf1 protein (also known as HNF-1alpha) also regulates transcription of the gene (Nr1h4) encoding the farnesoid X receptor-1 (Fxr-1), thereby leading to reduced expression of small heterodimer partner-1 (Shp-1) and repression of Cyp7a1, the rate-limiting enzyme in the classic bile acid biosynthesis pathway. |
| 4 | 11279518 | This is most likely due to reduced activity of the HDL-catabolic enzyme hepatic lipase (Lipc) and increased expression of HDL-cholesterol esterifying enzyme lecithin:cholesterol acyl transferase (Lcat). |
| 5 | 11279518 | Our studies demonstrate that Tcf1, in addition to being an important regulator of insulin secretion, is an essential transcriptional regulator of bile acid and HDL-cholesterol metabolism. |