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Gene Information

Gene symbol: SLC22A7

Gene name: solute carrier family 22 (organic anion transporter), member 7

HGNC ID: 10971

Synonyms: NLT, OAT2

Related Genes

#	Gene Symbol	Number of hits
1	ABCC3	1 hits
2	ABCC4	1 hits
3	NFKB1	1 hits
4	NQO1	1 hits
5	PRKCA	1 hits
6	SLC22A8	1 hits
7	SLC2A6	1 hits

Related Sentences

#	PMID	Sentence
1	8854860	The LX1 predicted protein is highly hydrophobic, possesses twelve putative transmembrane domains, and also shares significant homology with members of the sugar transporter family, particularly the novel liver-specific transporter NLT.
2	18189363	In kidney, Nqo1, Mrp3, 4, Oatp1a1, and organic anion transporter 2 (Oat2) showed significant alterations with mRNA expression levels in ob/ob mice, being increased for Nqo1 and Mrp4 and decreased for Mrp3, Oatp1a1, and Oat2.
3	18346469	Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes.
4	18346469	It is known that protein kinase C (PKC) signal transduction is enhanced in a diabetic state, and that PKC activator phorbol esters increase the gene expression of MDR1 in human tumor cells.
5	18346469	To clarify the expression of the liver transporters under diabetic conditions and the roles of PKCalpha and the transcription factor NF-kappaB, we investigated the expression levels of Mdr1a, Mdr1b, Mdr2, Mrp2, Bcrp, Bsep, Oct1, Oat2, and Oat3 transporters, PKCalpha, IkappaB, and NF-kappaB in the liver of rats with STZ-induced hyperglycemia.
6	18346469	NF-kappaB p65, IkappaBalpha and IkappaBbeta mRNA levels were increased as was the level of nuclear NF-kappaB p65.
7	18346469	From these findings, it was suggested that STZ-induced hyperglycemia caused the upregulation of Mdr1b P-gp expression through the activation of PKCalpha and NF-kappaB.