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PMID |
Sentence |
1 |
11929192
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Five proteins have been cloned, named UCP1, UCP2, UCP3, UCP4 and UCP5/BMCP1.
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2 |
11929192
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UCP1 is expressed uniquely in the brown adipose tissue, while UCP2 is widely distributed, UCP3 is mainly restricted to skeletal muscle and UCP4 and UCP5/BMCP1 expressed in the brain.
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3 |
11929192
|
Five proteins have been cloned, named UCP1, UCP2, UCP3, UCP4 and UCP5/BMCP1.
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4 |
11929192
|
UCP1 is expressed uniquely in the brown adipose tissue, while UCP2 is widely distributed, UCP3 is mainly restricted to skeletal muscle and UCP4 and UCP5/BMCP1 expressed in the brain.
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5 |
19413708
|
The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.
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6 |
19413708
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In mammals, more than five family members have been identified, including UCP1, UCP2, UCP3, UCP4 (or BMCP1/UCP5) and UCP5.
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7 |
19413708
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The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance.
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8 |
19413708
|
This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans.
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9 |
23841103
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The physiological functions of UCPs have long been debated since the new UCPs (UCP2 to 5) were discovered, and the role of UCPs in the pathogeneses of diabetes mellitus is one of the hottest topics.
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10 |
23841103
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UCP2 is expressed in several tissues and acts in the negative regulation of insulin secretion by β-cells and in fatty acid metabolism.
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11 |
23841103
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UCP3 plays a role in fatty acid metabolism and energy homeostasis and modulates insulin sensitivity.
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12 |
23841103
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Several gene polymorphisms of UCP1, UCP2, and UCP3 were reported to be associated with diabetes.
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13 |
23841103
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The progress in the role of UCP1, UCP2, and UCP3 on diabetes mellitus is summarized in this review.
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