Ignet

Gene Information

Gene symbol: SLC2A4RG

Gene name: SLC2A4 regulator

HGNC ID: 15930

Synonyms: GEF, HDBP1, Si-1-2, Si-1-2-19

Related Genes

#	Gene Symbol	Number of hits
1	EBF1	1 hits
2	KLF15	1 hits
3	KLF2	1 hits
4	MYEF2	1 hits
5	MYOD1	1 hits
6	NF1	1 hits
7	RCC1	1 hits
8	RHOD	1 hits
9	SLC2A4	1 hits

Related Sentences

#	PMID	Sentence
1	12101123	Its NIMA-like catalytic domain is followed by a noncatalytic tail containing seven repeats homologous to those of the Ran GEF, RCC1, a Ser/Thr/Pro-rich segment, and a coiled-coil domain.
2	12101123	Nercc1 binds to another NIMA-like kinase, Nek6, and also binds specifically to the Ran GTPase through both its catalytic and its RCC1-like domains, preferring RanGDP in vivo.
3	12101123	Nercc1 and its partner Nek6 represent a new signaling pathway that regulates mitotic progression.
4	15235326	These DNA elements have been shown to bind the transcription factors myocyte enhancer factor 2 (MEF2) and GLUT4 enhancer factor (GEF).
5	15235326	Signals that link muscle contraction to the activation of transcription factors (MEF2, GEF) involved in increased expression of GLUT4 during exercise is another area needing further research.
6	15235326	Two signals that show promise are changes in the energy charge (acting through AMP activated kinase [AMPK]) and changes in intracellular calcium (acting through calcineurin [a calcium-calmodulin activated phosphatase] and calcium-calmodulin activated kinase [CAMK]).
7	15235326	There is good evidence that both increased AMPK activity and increased CAMK activity cause increased transcription of the GLUT4 gene.
8	15235326	These DNA elements have been shown to bind the transcription factors myocyte enhancer factor 2 (MEF2) and GLUT4 enhancer factor (GEF).
9	15235326	Signals that link muscle contraction to the activation of transcription factors (MEF2, GEF) involved in increased expression of GLUT4 during exercise is another area needing further research.
10	15235326	Two signals that show promise are changes in the energy charge (acting through AMP activated kinase [AMPK]) and changes in intracellular calcium (acting through calcineurin [a calcium-calmodulin activated phosphatase] and calcium-calmodulin activated kinase [CAMK]).
11	15235326	There is good evidence that both increased AMPK activity and increased CAMK activity cause increased transcription of the GLUT4 gene.
12	15654919	GLUT4 expression is exquisitely regulated in muscle and this seems important in the regulation of insulin-stimulated glucose uptake by this tissues.
13	15654919	Thus, muscle GLUT4 overexpression in transgenic animals ameliorates insulin resistance associated with obesity or diabetes.
14	15654919	Recent information indicates that glut4 gene transcription is regulated by a number of factors in skeletal muscle that include MEF2, MyoD myogenic proteins, thyroid hormone receptors, Kruppel-like factor KLF15, NF1, Olf-1/Early B cell factor and GEF/HDBP1.
15	15654919	In addition, studies in vivo indicate that under normal conditions the activity of the muscle-specific GLUT4 enhancer is low in adult skeletal muscle compared with the maximal potential activity that it can attain at high levels of the MRF transcription factors, MEF2, and TRalpha1.
16	18222728	Recent advances in Rho protein signaling research indicate that the Rho exchange factors (Rho GEFs) which activate Rho proteins by catalyzing the exchange of GDP for GTP are major regulators of Rho protein activity.
17	18222728	In addition, linkage analysis and association studies have recently identified Rho GEFs as susceptibility genes for cardiovascular diseases.
18	18222728	All of these data are converging to suggest that as upstream activators of Rho proteins, Rho GEFs expressed in cardiovascular cells are good candidate targets for the treatment of cardiovascular disorders.
19	18222728	Recent advances in Rho protein signaling research indicate that the Rho exchange factors (Rho GEFs) which activate Rho proteins by catalyzing the exchange of GDP for GTP are major regulators of Rho protein activity.
20	18222728	In addition, linkage analysis and association studies have recently identified Rho GEFs as susceptibility genes for cardiovascular diseases.
21	18222728	All of these data are converging to suggest that as upstream activators of Rho proteins, Rho GEFs expressed in cardiovascular cells are good candidate targets for the treatment of cardiovascular disorders.
22	18222728	Recent advances in Rho protein signaling research indicate that the Rho exchange factors (Rho GEFs) which activate Rho proteins by catalyzing the exchange of GDP for GTP are major regulators of Rho protein activity.
23	18222728	In addition, linkage analysis and association studies have recently identified Rho GEFs as susceptibility genes for cardiovascular diseases.
24	18222728	All of these data are converging to suggest that as upstream activators of Rho proteins, Rho GEFs expressed in cardiovascular cells are good candidate targets for the treatment of cardiovascular disorders.