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Gene Information

Gene symbol: SLC2A8

Gene name: solute carrier family 2 (facilitated glucose transporter), member 8

HGNC ID: 13812

Synonyms: GLUTX1, GLUT8

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	SLC2A1	1 hits
3	SLC2A10	1 hits
4	SLC2A11	1 hits
5	SLC2A12	1 hits
6	SLC2A14	1 hits
7	SLC2A2	1 hits
8	SLC2A3P1	1 hits
9	SLC2A4	1 hits
10	SLC2A5	1 hits
11	SLC2A6	1 hits
12	SLC2A7	1 hits
13	SLC5A1	1 hits

Related Sentences

#	PMID	Sentence
1	8911988	Freshly isolated rat cardiomyocytes, primary cultured cardiomyocytes and the cardiac cell line H9c2 were used to elucidate acute and chronic effects of the sulfonylurea glimepiride on basal and insulin-stimulated glucose uptake and on the expression of the transporter isoforms GLUT1 and GLUT4.
2	8911988	In the former cells the sulfonylurea increased the expression of both GLUT1 and GLUT4 to 164 +/- 21 and 148 +/- 5% of control, respectively.
3	8911988	It is concluded that glimepiride increases cardiac glucose uptake by an insulin-independent pathway most probably involving an increased protein expression of GLUT1 and GLUT4.
4	11237212	Intracellular organization of insulin signaling and GLUT4 translocation.
5	11237212	Currently, there are five established functional facilitative glucose transporter isoforms (GLUT1-4 and GLUTX1), with GLUT5 being a fructose transporter.
6	11237212	GLUT3 is expressed primarily in neurons and, together, GLUT1 and GLUT3 allow glucose to cross the blood-brain barrier and enter neurons.
7	11237212	The GLUT4 isoform is the major insulin-responsive transporter that is predominantly restricted to striated muscle and adipose tissue.
8	11237212	In contrast to the other GLUT isoforms, which are primarily localized to the cell surface membrane, GLUT4 transporter proteins are sequestered into specialized storage vesicles that remain within the cell's interior under basal conditions.
9	11237212	As postprandial glucose levels rise, the subsequent increase in circulating insulin activates intracellular signaling cascades that ultimately result in the translocation of the GLUT4 storage compartments to the plasma membrane.
10	11237212	Importantly, this process is readily reversible such that when circulating insulin levels decline, GLUT4 transporters are removed from the plasma membrane by endocytosis and are recycled back to their intracellular storage compartments.
11	11237212	Therefore, by establishing an internal membrane compartment as the default localization for the GLUT4 transporters, insulin-responsive tissues are poised to respond rapidly and efficiently to fluctuations in circulating insulin levels.
12	11237212	This chapter will focus on recently elucidated insulin signal transduction pathways and GLUT4 vesicle trafficking components that are necessary for insulin-stimulated glucose uptake and GLUT4 translocation in adipocytes.
13	12271485	These results demonstrate that GLUT8 undergoes rapid translocation to the rough ER in the rat hippocampus following peripheral glucose administration, trafficking that is impaired in STZ diabetes, suggesting that insulin serves as a stimulus for GLUT8 translocation in hippocampal neurons.
14	12697674	In diabetic scenarios, GLUT8 mRNA levels were correlated with circulating insulin; specifically, GLUT8 mRNA decreased in a type 1 diabetes model and increased in a type 2 diabetes model, suggesting a regulatory role for insulin in GLUT8 mRNA expression.
15	15741607	Additionally, GLUT8 expression was studied using two different models of insulin resistance, GLUT4-/- and db/db mice.
16	19756716	Sodium-dependent glucose cotransporter 1 (SGLT1), glucose transporter (GLUT)1, GLUT2, and GLUT8 transcripts were detected by reverse transcriptase polymerase chain reaction in isolated ducts.
17	20224212	Pancreatic duct cells express Na(+)-dependent glucose transporter, SGLT1 and Na(+)-independent glucose transporters, GLUT1, GLUT2, and GLUT8.