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Gene Information

Gene symbol: SLC38A2

Gene name: solute carrier family 38, member 2

HGNC ID: 13448

Synonyms: SAT2, ATA2, KIAA1382, SNAT2

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	ATF4	1 hits
3	CRTC1	1 hits
4	CRTC2	1 hits
5	LAT	1 hits
6	SLC7A5	1 hits

Related Sentences

#	PMID	Sentence
1	9648821	Phosphatidylinositol 3-kinase (PI 3-kinase) has been implicated in the regulation of numerous cellular processes, including the insulin-induced regulation of glycogen synthase kinase 3 (GSK-3) and glucose transport.
2	9648821	The hormonal-induced inactivation of GSK-3 is mediated by protein kinase B (PKB), a downstream target of PI 3-kinase, whose involvement in other insulin-stimulated responses remains poorly defined at present.
3	9648821	Both wtPKBalpha and mPKBalpha expression led to a significant increase in the basal uptake of glucose and methyl-aminoisobutyric acid (a substrate for the system A amino acid transporter), at least to a level seen in control cells treated with insulin.
4	9648821	In the absence of insulin, only muscle cells expressing the constitutively active PKBalpha showed a significant increase in protein synthesis and an inhibition in GSK-3.
5	9648821	These observations imply that PKBalpha may have a role in the insulin-regulated control of these processes in skeletal muscle.
6	22215663	SNAT2 expression and activity are up-regulated by arsenite, in a manner dependent on activating transcription factor 4 (ATF4), an important mediator of the integrated stress response.
7	22215663	Importantly, inhibition of the SNAT2 or the System L transporter, LAT1, suppressed mTOR activation by arsenite, supporting a role for these transporters in modulating amino acid signaling.
8	22215663	SNAT2 expression and activity are up-regulated by arsenite, in a manner dependent on activating transcription factor 4 (ATF4), an important mediator of the integrated stress response.
9	22215663	Importantly, inhibition of the SNAT2 or the System L transporter, LAT1, suppressed mTOR activation by arsenite, supporting a role for these transporters in modulating amino acid signaling.
10	23165769	In contrast, mTOR inhibition had no effect on serotonin transport. mTORC1 or mTORC2 silencing markedly decreased the plasma membrane expression of specific System A (SNAT2, SLC38A2) and System L (LAT1, SLC7A5) transporter isoforms without affecting global protein expression.
11	23165769	In conclusion, mTORC1 and mTORC2 regulate human trophoblast amino acid transporters by modulating the cell surface abundance of specific transporter isoforms.