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Gene Information
Gene symbol: SLC7A2
Gene name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
HGNC ID: 11060
Synonyms: CAT-2, HCAT2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PTPN1 | 1 hits |
| 2 | SLC7A1 | 1 hits |
| 3 | SLC7A10 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11384198 | Citrulline formed by the NOS reaction is recycled to arginine by the citrulline-NO cycle, which is composed of NOS, argininosuccinate synthetase (AS), and argininosuccinate lyase. |
| 2 | 11384198 | Cationic amino acid transporter (CAT)-1 mRNA remained little changed, and CAT-2 mRNA was not detected. |
| 3 | 11384198 | Transforming growth factor-beta1 (TGF-beta1) mRNA in the aorta was also induced. |
| 4 | 11384198 | TGF-beta1 induced eNOS and AS mRNAs in human umbilical vein endothelial cells but inhibited the proliferation of HUVEC. |
| 5 | 11384198 | These results indicate that eNOS and AS are coinduced in the aorta in early stages of STZ-induced diabetic rats and that the induction is mediated by TGF-beta1. |
| 6 | 17135270 | Protein tyrosine phosphatase 1B (PTP-1B) has been implicated in the regulation of the insulin receptor. |
| 7 | 17135270 | PTP-1B-/- mice have increased insulin sensitivity and are resistant to weight gain when fed a high fat diet, validating PTP-1B as a potential target for the treatment of type 2 diabetes. |
| 8 | 17135270 | Using two constructs of PTP-1B and a phosphopeptide as substrate, steady state assays showed that the presence of the C-terminal domain decreased both the Km and the k(cat) 2-fold. |