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Gene Information
Gene symbol: SLCO2B1
Gene name: solute carrier organic anion transporter family, member 2B1
HGNC ID: 10962
Synonyms: OATP-B, OATP2B1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCC2 | 1 hits |
| 2 | ABCC4 | 1 hits |
| 3 | SLC15A1 | 1 hits |
| 4 | SLC22A2 | 1 hits |
| 5 | SLC22A6 | 1 hits |
| 6 | SLC22A8 | 1 hits |
| 7 | SLCO4C1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17314201 | Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. |
| 2 | 17314201 | In this report, we demonstrate that sitagliptin is transported by human organic anion transporter hOAT3 (Km=162 microM), organic anion transporting polypeptide OATP4C1, and multidrug resistance (MDR) P-glycoprotein (Pgp), but not by human organic cation transporter 2 hOCT2, hOAT1, oligopeptide transporter hPEPT1, OATP2B1, and the multidrug resistance proteins MRP2 and MRP4. |
| 3 | 17314201 | Our studies suggested that hOAT3, OATP4C1, and MDR1 Pgp might play a role in transporting sitagliptin into and out of renal proximal tubule cells, respectively. |
| 4 | 17314201 | Our data indicate that sitagliptin is unlikely to be a perpetrator of drug-drug interactions with Pgp, hOAT1, or hOAT3 substrates at clinically relevant concentrations. |