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Gene Information
Gene symbol: SNAI2
Gene name: snail homolog 2 (Drosophila)
HGNC ID: 11094
Synonyms: SLUGH1, SNAIL2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ITK | 1 hits |
| 2 | TGFB1 | 1 hits |
| 3 | TWIST1 | 1 hits |
| 4 | ZEB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21088486 | Transforming Growth Factor-b (TGFb) is a major driving force of the Epithelial-to-Mesenchymal (EMT) genetic program, which becomes overactive in the pathophysiology of many age-related human diseases. |
| 2 | 21088486 | TGFb-driven EMT is sufficient to generate migrating cancer stem cells by directly linking the acquisition of cellular motility with the maintenance of tumor-initiating (stemness) capacity. |
| 3 | 21088486 | Chronic diseases exhibiting excessive fibrosis can be caused by repeated and sustained infliction of TGFb-driven EMT, which increases collagen and extracellular matrix synthesis. |
| 4 | 21088486 | Pharmacological prevention and/or reversal of TGFb-induced EMT may therefore have important clinical applications in the management of cancer metastasis as well as in the prevention and/or treatment of end-state organ failures. |
| 5 | 21088486 | ZEB1, TWIST1, SNAIL2 [Slug], TGFbs), we recently hypothesized that prevention of TGFb-induced EMT might represent a common molecular mechanism underlying the anti-cancer stem cells and anti-fibrotic actions of metformin. |
| 6 | 21088486 | Remarkably, metformin exposure not only impedes TGFb-promoted loss of the epithelial marker E-cadherin in MCF-7 breast cancer cells but it prevents further TGF-induced cell scattering and accumulation of the mesenchymal marker vimentin in Madin-Darby canine kidney (MDCK) cells. |