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Gene Information
Gene symbol: SNAPIN
Gene name: SNAP-associated protein
HGNC ID: 17145
Synonyms: BLOC1S7
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | SNAP25 | 1 hits |
| 3 | TMEM27 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16330323 | The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. |
| 2 | 16330323 | Overexpression of collectrin in rat insulinoma INS-1 cells or in the beta cells of transgenic mice enhanced glucose-stimulated insulin exocytosis, without affecting Ca(2+) influx. |
| 3 | 16330323 | Conversely, suppression of collectrin attenuated insulin secretion. |
| 4 | 16330323 | Collectrin bound to SNARE complexes by interacting with snapin, a SNAP-25 binding protein, and facilitated SNARE complex formation. |
| 5 | 16330323 | Therefore, collectrin is a regulator of SNARE complex function, which thereby controls insulin exocytosis. |
| 6 | 21356520 | Snapin mediates incretin action and augments glucose-dependent insulin secretion. |
| 7 | 21356520 | Treatment with the incretin hormone glucagon-like peptide-1 (GLP-1) potentiates insulin secretion and improves metabolic control in humans with T2DM. |
| 8 | 21356520 | GLP-1 receptor-mediated signaling leading to insulin secretion occurs via cyclic AMP stimulated protein kinase A (PKA)- as well as guanine nucleotide exchange factor-mediated pathways. |