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Gene Information
Gene symbol: SNX19
Gene name: sorting nexin 19
HGNC ID: 21532
Synonyms: KIAA0254, CHET8
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | PTPRN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17725654 | IA-2 also is an intrinsic transmembrane component of dense core secretory vesicles and knock-out studies showed that IA-2 is a regulator of insulin secretion. |
| 2 | 17725654 | Treatment of IA-2-transfected cells with IA-2 siRNA prevented both G2/M arrest and apoptosis and increased Akt/PKB phosphorylation. |
| 3 | 17725654 | A search for IA-2 interacting proteins revealed that IA-2 interacts with sorting nexin (SNX)19 and that SNX19, but not IA-2, inhibits the conversion of PtdIns(4,5)P2 to PtdIns(3,4,5)P3 and thereby suppresses the phosphorylation of proteins in the Akt signalling pathway resulting in apoptosis. |
| 4 | 17725654 | We conclude that IA-2 acts through SNX19 to initiate the pre-apoptotic state. |
| 5 | 17725654 | IA-2 also is an intrinsic transmembrane component of dense core secretory vesicles and knock-out studies showed that IA-2 is a regulator of insulin secretion. |
| 6 | 17725654 | Treatment of IA-2-transfected cells with IA-2 siRNA prevented both G2/M arrest and apoptosis and increased Akt/PKB phosphorylation. |
| 7 | 17725654 | A search for IA-2 interacting proteins revealed that IA-2 interacts with sorting nexin (SNX)19 and that SNX19, but not IA-2, inhibits the conversion of PtdIns(4,5)P2 to PtdIns(3,4,5)P3 and thereby suppresses the phosphorylation of proteins in the Akt signalling pathway resulting in apoptosis. |
| 8 | 17725654 | We conclude that IA-2 acts through SNX19 to initiate the pre-apoptotic state. |