Ignet

Gene Information

Gene symbol: SOS1

Gene name: son of sevenless homolog 1 (Drosophila)

HGNC ID: 11187

Synonyms: HGF, GF1

Related Genes

#	Gene Symbol	Number of hits
1	FLNA	1 hits
2	INS	1 hits
3	INSR	1 hits
4	MAPK1	1 hits
5	PIK3R1	1 hits
6	RASA1	1 hits
7	SHC1	1 hits

Related Sentences

#	PMID	Sentence
1	12734206	Interaction of filamin A with the insulin receptor alters insulin-dependent activation of the mitogen-activated protein kinase pathway.
2	12734206	Even though this event requires the participation of actin-binding proteins, the effect of filamin A (FLNa) on insulin-mediated signaling events is still unknown.
3	12734206	We report here that human melanoma M2 cells lacking FLNa expression exhibited normal insulin receptor (IR) signaling, whereas FLNa-expressing A7 cells were unable to elicit insulin-dependent Shc tyrosine phosphorylation and p42/44 MAPK activation despite no significant defect in IR-stimulated phosphorylation of insulin receptor substrate-1 or activation of the phosphatidylinositol 3-kinase/AKT cascade.
4	12734206	Insulin-dependent translocation of Shc, SOS1, and MAPK to lipid raft microdomains was markedly attenuated by FLNa expression.
5	12734206	Coimmunoprecipitation experiments and in vitro binding assays demonstrated that FLNa binds constitutively to IR and that neither insulin nor depolymerization of actin by cytochalasin D affected this interaction.
6	12734206	Ectopic expression of a C-terminal fragment of FLNa (FLNaCT) in HepG2 cells blocked the endogenous IR-FLNa interaction and potentiated insulin-stimulated MAPK phosphorylation and transactivation of Elk-1 compared with vector-transfected cells.
7	12734206	Expression of FLNaCT had no major effect on insulin-induced phosphorylation of the IR, insulin receptor substrate-1, or AKT, but it elicited changes in actin cytoskeletal structure and ruffle formation in HepG2 cells.
8	12734206	Taken together, these results indicate that FLNa interacts constitutively with the IR to exert an inhibitory tone along the MAPK activation pathway.
9	14551916	Polymorphisms in five of 15 genes (33%) encoding molecules known to primarily influence pancreatic beta-cell function-ABCC8 (sulphonylurea receptor), KCNJ11 (KIR6.2), SLC2A2 (GLUT2), HNF4A (HNF4alpha), and INS (insulin)-significantly altered disease risk, and in three genes, the risk allele, haplotype, or both had a biologically consistent effect on a relevant physiological trait in the QT study.
10	14551916	We examined 35 genes predicted to have their major influence on insulin action, and three (9%)-INSR, PIK3R1, and SOS1-showed significant associations with diabetes.
11	15010862	Normal p21Ras/MAP kinase pathway expression and function in PBMC from patients with polycystic ovary disease.
12	15010862	The p21Ras/MAP kinase is a major intracellular signaling pathway mediating insulin signaling in insulin responsive tissues.
13	15010862	The expression, regulation and function of the p21Ras/MAP kinase pathway in PCOD patients were examined.
14	15010862	The expression of p21Ras and its regulatory proteins; hSOS1 and p120GAP were studied.
15	15010862	The basal and phytohemaglutinin (PHA) or insulin stimulated phosphorylation of MAP kinase was determined.
16	15010862	Expression of p21Ras, and its regulatory proteins hSOS1 and p120GAP were similar in PCOD patients and controls.
17	15010862	Basal, PHA and insulin stimulated phosphorylation of MAP kinase, were also comparable in the two groups as well as their PBMC proliferative response.
18	15010862	These data indicate that the expression and overall function of the p21Ras/MAP kinase pathway remain intact in non-diabetic patients with PCOD.
19	15010862	Normal p21Ras/MAP kinase pathway expression and function in PBMC from patients with polycystic ovary disease.
20	15010862	The p21Ras/MAP kinase is a major intracellular signaling pathway mediating insulin signaling in insulin responsive tissues.
21	15010862	The expression, regulation and function of the p21Ras/MAP kinase pathway in PCOD patients were examined.
22	15010862	The expression of p21Ras and its regulatory proteins; hSOS1 and p120GAP were studied.
23	15010862	The basal and phytohemaglutinin (PHA) or insulin stimulated phosphorylation of MAP kinase was determined.
24	15010862	Expression of p21Ras, and its regulatory proteins hSOS1 and p120GAP were similar in PCOD patients and controls.
25	15010862	Basal, PHA and insulin stimulated phosphorylation of MAP kinase, were also comparable in the two groups as well as their PBMC proliferative response.
26	15010862	These data indicate that the expression and overall function of the p21Ras/MAP kinase pathway remain intact in non-diabetic patients with PCOD.