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Gene Information
Gene symbol: SP4
Gene name: Sp4 transcription factor
HGNC ID: 11209
Synonyms: SPR-1, HF1B, MGC130008, MGC130009
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | SP1 | 1 hits |
| 2 | SP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11250945 | Insulin deprivation leads to deficiency of Sp1 transcription factor in H-411E hepatoma cells and in streptozotocin-induced diabetic ketoacidosis in the rat. |
| 2 | 11250945 | Members of the family of Sp transcription factors include Sp1, Sp3, and Sp4 and are important regulators of eukaryotic gene expression. |
| 3 | 11250945 | To test whether other members of the Sp family are direct targets of insulin action, we compared the levels of Sp1 and Sp3 proteins from nuclear extracts obtained from both insulin-treated and untreated rat hepatoma (H-411E) cells. |
| 4 | 11250945 | We demonstrated by Western blot analysis that levels of Sp1 and Sp3 proteins were increased more than 2-fold in the insulin-treated group. |
| 5 | 11250945 | Additionally, the up-regulation of both Sp1 and Sp3 transcription factors by insulin was antagonized by tumor necrosis factor-alpha, a known inhibitor of insulin action. |
| 6 | 11250945 | Immunohistochemical analysis demonstrated that H-411E cells treated with insulin (10,000 microU/ml) had a marked increase in demonstrable Sp1 in the nucleus compared with cells incubated in insulin-free medium. |
| 7 | 11250945 | We demonstrated in rat liver tissue by both Western blot and immunohistochemical staining with anti-Sp1 antibody that 1) livers of fully diabetic streptozotocin rats have low levels of Sp1 transcription factor; and 2) insulin treatment of the diabetic rat rapidly reversed this process by markedly stimulating accumulation of Sp1 in rat liver. |
| 8 | 11250945 | Studies of the signal transduction mechanisms involved in insulin's effect on Sp1 demonstrate a facilitating role for phosphoinositol 3-kinase and an inhibitory role for cyclic nucleotides. |
| 9 | 11250945 | In summary, insulin stimulates Sp1 protein, a transcription factor that is shown to regulate calmodulin gene expression and most likely other, as yet untested, genes. |
| 10 | 12383520 | Transfection of Drosophila SL2 cells, which lack Sp/Krüppel-like factors, with constructs encoding either Sp1, Sp3, Sp4 or erythroid Krüppel-like factor (EKLF) specifically activates the hmGPD promoter B up to 50-fold. |
| 11 | 12383520 | Co-transfected EKLF was synergistic with either Sp1 or Sp3. |