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Gene Information
Gene symbol: SPAM1
Gene name: sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
HGNC ID: 11217
Synonyms: HYAL5, PH-20, SPAG15
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23349492 | The hypotheses that 1) HA content is increased in the ECM of insulin-resistant skeletal muscle and 2) reduction of HA in the muscle ECM by long-acting pegylated human recombinant PH20 hyaluronidase (PEGPH20) reverses high-fat (HF) diet-induced muscle insulin resistance were tested. |
| 2 | 23349492 | We show that muscle HA was increased in HF diet-induced obese (DIO) mice and that treatment of PEGPH20, which dose-dependently reduced HA in muscle ECM, decreased fat mass, adipocyte size, and hepatic and muscle insulin resistance in DIO mice at 10 mg/kg. |