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Gene Information
Gene symbol: SPOP
Gene name: speckle-type POZ protein
HGNC ID: 11254
Synonyms: TEF2, BTBD32
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PCIF1 | 1 hits |
| 2 | PDX1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15121856 | Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. |
| 2 | 15121856 | Pancreatic-duodenal homeobox 1 (PDX-1) is a Hox-type protein that is a critical requirement for normal pancreas development and for proper differentiation of the endocrine pancreas. |
| 3 | 15121856 | We have identified a novel POZ domain protein, PDX-1 C terminus-interacting factor 1 (PCIF1)/SPOP, that interacts with PDX-1 both in vitro and in vivo. |
| 4 | 15121856 | PCIF1 is localized to the nucleus in a speckled pattern, and coexpression of PDX-1 alters the subnuclear distribution of PCIF1. |
| 5 | 15121856 | Functionally, PCIF1 inhibits PDX-1 transactivation of established target gene promoters in a specific and dose-dependent manner that requires critical amino acids in the PDX-1 C terminus. |
| 6 | 15121856 | PCIF1 is expressed in adult pancreatic insulin-producing beta cells, and overexpression of PCIF1 inhibits the rat insulin 1 and rat insulin 2 promoters in the MIN6 insulinoma beta cell line. |
| 7 | 15121856 | The coexpression of PCIF1 with PDX-1 in beta cells and the ability of PCIF1 to repress PDX-1 transactivation suggest that modulation of PDX-1 function by PCIF1 may regulate normal beta cell differentiation. |