Ignet

Gene Information

Gene symbol: SS18L1

Gene name: synovial sarcoma translocation gene on chromosome 18-like 1

HGNC ID: 15592

Synonyms: KIAA0693

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	PDX1	1 hits
3	SYT1	1 hits

Related Sentences

#	PMID	Sentence
1	15144884	Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression.
2	15144884	However, the role of Pdx-1 in the regulation of insulin release is not well established.
3	15144884	We previously demonstrated that Pdx-1 overcomes the defect in insulin release from the insulin-producing cells derived from small hepatocytes (SHCs).
4	15144884	In the present study, we identified a new target of Pdx-1 involved in insulin release.
5	15144884	Pdx-1 positively regulates the transcription of the gene encoding synaptotagmin 1 (Syt1) (a Ca(2+)-sensor that plays a central role in insulin release) through Pdx-1-binding sites within the 3' regulatory region of the Syt1 gene.
6	15144884	We further demonstrated the essential role of Pdx-1 in insulin secretion by the gene knock-down strategy.
7	15144884	Small interfering RNA (siRNA) directed against Pdx-1 specifically reduced the levels of Pdx-1 protein and Syt1 transcript in insulinoma lines.
8	15144884	Our data indicate that Pdx-1 might contribute to the regulation of insulin release by promoting Syt1 expression in vivo, and provide useful information for future therapy of diabetes mellitus.
9	15144884	Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression.
10	15144884	However, the role of Pdx-1 in the regulation of insulin release is not well established.
11	15144884	We previously demonstrated that Pdx-1 overcomes the defect in insulin release from the insulin-producing cells derived from small hepatocytes (SHCs).
12	15144884	In the present study, we identified a new target of Pdx-1 involved in insulin release.
13	15144884	Pdx-1 positively regulates the transcription of the gene encoding synaptotagmin 1 (Syt1) (a Ca(2+)-sensor that plays a central role in insulin release) through Pdx-1-binding sites within the 3' regulatory region of the Syt1 gene.
14	15144884	We further demonstrated the essential role of Pdx-1 in insulin secretion by the gene knock-down strategy.
15	15144884	Small interfering RNA (siRNA) directed against Pdx-1 specifically reduced the levels of Pdx-1 protein and Syt1 transcript in insulinoma lines.
16	15144884	Our data indicate that Pdx-1 might contribute to the regulation of insulin release by promoting Syt1 expression in vivo, and provide useful information for future therapy of diabetes mellitus.
17	15144884	Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression.
18	15144884	However, the role of Pdx-1 in the regulation of insulin release is not well established.
19	15144884	We previously demonstrated that Pdx-1 overcomes the defect in insulin release from the insulin-producing cells derived from small hepatocytes (SHCs).
20	15144884	In the present study, we identified a new target of Pdx-1 involved in insulin release.
21	15144884	Pdx-1 positively regulates the transcription of the gene encoding synaptotagmin 1 (Syt1) (a Ca(2+)-sensor that plays a central role in insulin release) through Pdx-1-binding sites within the 3' regulatory region of the Syt1 gene.
22	15144884	We further demonstrated the essential role of Pdx-1 in insulin secretion by the gene knock-down strategy.
23	15144884	Small interfering RNA (siRNA) directed against Pdx-1 specifically reduced the levels of Pdx-1 protein and Syt1 transcript in insulinoma lines.
24	15144884	Our data indicate that Pdx-1 might contribute to the regulation of insulin release by promoting Syt1 expression in vivo, and provide useful information for future therapy of diabetes mellitus.