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Gene Information
Gene symbol: ST2
Gene name: suppression of tumorigenicity 2
HGNC ID: 11347
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | FOXP3 | 1 hits |
| 3 | SRA1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21152033 | Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity. |
| 2 | 21152033 | Overexpression of SRA in ST2 mesenchymal precursor cells promotes their differentiation into adipocytes. |
| 3 | 21152033 | Microarray analysis reveals hundreds of SRA-responsive genes in adipocytes, including genes involved in the cell cycle, and insulin and TNFα signaling pathways. |
| 4 | 21152033 | SRA in adipocytes increases both glucose uptake and phosphorylation of Akt and FOXO1 in response to insulin. |
| 5 | 21152033 | SRA promotes S-phase entry during mitotic clonal expansion, decreases expression of the cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1, and increases phosphorylation of Cdk1/Cdc2. |
| 6 | 21152033 | SRA also inhibits the expression of adipocyte-related inflammatory genes and TNFα-induced phosphorylation of c-Jun NH(2)-terminal kinase. |
| 7 | 21152033 | In conclusion, SRA enhances adipogenesis and adipocyte function through multiple pathways. |
| 8 | 23142275 | Cyclophosphamide (CY) in the dose of 175 mg/kg b.w. eliminated CD4+Foxp3+ regulatory T cells (Tregs) and enhanced disease severity in C57/BL6 mice, but it did not overcome resistance to diabetes in BALB/c mice and did not affect diabetes progression in ST2 knock-out (ST2KO) mice. |
| 9 | 23142275 | This treatment eliminated Tregs in pancreatic lymph nodes in ST2KO mice, while markedly increasing the influx of CD8+, CD4+TNF-α+, and CD4+IFN-γ+ effector T cells (Teffs) in pancreata. |
| 10 | 23142275 | Taken together, our data suggest that the prevailing Th2 immune response in BALB/c mice may be responsible for the resistance to MLD-STZ diabetes and that ST2 gene deletion reveals the role of highly cyclophosphamide sensitive CD4+Foxp3+ regulatory T cells in the pancreatic lymph nodes in diabetes modulation. |
| 11 | 23142275 | Cyclophosphamide (CY) in the dose of 175 mg/kg b.w. eliminated CD4+Foxp3+ regulatory T cells (Tregs) and enhanced disease severity in C57/BL6 mice, but it did not overcome resistance to diabetes in BALB/c mice and did not affect diabetes progression in ST2 knock-out (ST2KO) mice. |
| 12 | 23142275 | This treatment eliminated Tregs in pancreatic lymph nodes in ST2KO mice, while markedly increasing the influx of CD8+, CD4+TNF-α+, and CD4+IFN-γ+ effector T cells (Teffs) in pancreata. |
| 13 | 23142275 | Taken together, our data suggest that the prevailing Th2 immune response in BALB/c mice may be responsible for the resistance to MLD-STZ diabetes and that ST2 gene deletion reveals the role of highly cyclophosphamide sensitive CD4+Foxp3+ regulatory T cells in the pancreatic lymph nodes in diabetes modulation. |