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Gene Information
Gene symbol: ST6GAL1
Gene name: ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
HGNC ID: 10860
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AP3S2 | 1 hits |
| 2 | B4GALT1 | 1 hits |
| 3 | CDKAL1 | 1 hits |
| 4 | FUT8 | 1 hits |
| 5 | GRB14 | 1 hits |
| 6 | HMG20A | 1 hits |
| 7 | HNF4A | 1 hits |
| 8 | INS | 1 hits |
| 9 | MGAT3 | 1 hits |
| 10 | PTPRD | 1 hits |
| 11 | ST3GAL2 | 1 hits |
| 12 | SUV420H1 | 1 hits |
| 13 | VPS26A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8429037 | The present study, utilizing the hormone-responsive rat thyroid cell line FRTL-5, presents evidence establishing the regulatory role of thyrotropin in modulating mRNA for beta-galactoside alpha 2,6-sialytransferase, the enzyme responsible for the expression of alpha 2,6-linked sialic acid. |
| 2 | 21874001 | In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1.9 × 10(-11)). |
| 3 | 21874001 | SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 × 10(-4)), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). |
| 4 | 21874001 | In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1.9 × 10(-11)). |
| 5 | 21874001 | SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 × 10(-4)), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). |
| 6 | 22216278 | We have used our Lebanese cohort to perform a replication study of nine previously identified CAD/MI susceptibility loci (LTA, CDKN2A-CDKN2B, CELSR2-PSRC1-SORT1, CXCL12, MTHFD1L, WDR12, PCSK9, SH2B3, and SLC22A3), and 88 genes in related phenotypes. |
| 7 | 22216278 | This approach replicated HNRNPA3P1-CXCL12 association with CAD and identified new significant associations of CDKAL1, ST6GAL1, and PTPRD with CAD. |
| 8 | 23382691 | Meta-analysis of genome-wide association study (GWAS) results identified 9 genome-wide significant loci (P<2.27 × 10(-9)) in the discovery analysis and two of the same loci (B4GALT1 and MGAT3) in the replication cohort. |
| 9 | 23382691 | Four loci contained genes encoding glycosyltransferases (ST6GAL1, B4GALT1, FUT8, and MGAT3), while the remaining 5 contained genes that have not been previously implicated in protein glycosylation (IKZF1, IL6ST-ANKRD55, ABCF2-SMARCD3, SUV420H1, and SMARCB1-DERL3). |