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Gene Information
Gene symbol: STS
Gene name: steroid sulfatase (microsomal), isozyme S
HGNC ID: 11425
Synonyms: ARSC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ARSH | 1 hits |
| 2 | CFP | 1 hits |
| 3 | DHCR7 | 1 hits |
| 4 | ELK1 | 1 hits |
| 5 | PCTK1 | 1 hits |
| 6 | RBM10 | 1 hits |
| 7 | RP2 | 1 hits |
| 8 | TIMP1 | 1 hits |
| 9 | UBA1 | 1 hits |
| 10 | USP11 | 1 hits |
| 11 | UXT | 1 hits |
| 12 | ZNF157 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 3610255 | In support of the latter, strain differences were demonstrated in activity levels of steroid sulfatase, which is regulated by a sex-linked gene likely expressed on both the X and Y chromosome, and which may control tissue levels of active androgens and estrogens. |
| 2 | 6159813 | Recent data on the steroid sulfatase gene suggest that not all X-linked genes are susceptible to inactivation. |
| 3 | 11944989 | A combination of chromosome walking and sequence-tagged site (STS)-content mapping resulted in an integrated framework and transcript map, precisely positioning 10 polymorphic microsatellites (one of which is novel), 16 ESTs, and 12 known genes (RP2, PCTK1, UHX1, UBE1, RBM10, ZNF157, SYN1, ARAF1, TIMP1, PFC, ELK1, UXT). |
| 4 | 11944989 | By a combination of EST database searches and in silico detection of UniGene clusters within genomic sequence generated from this template map, we have mapped several novel genes within this interval: a Na+/H+ exchanger (SLC9A7), at least two zincfinger transcription factors (KIAA0215 and Hs.68318), carbohydrate sulfotransferase-7 (CHST7), regucalcin (RGN), inactivation-escape-1 (INE1), the human ortholog of mouse neuronal protein 15.6, and four putative novel genes. |
| 5 | 16390921 | Low estriol levels in the maternal triple-marker screen as a predictor of isolated adrenocorticotropic hormone deficiency caused by a new mutation in the TPIT gene. |
| 6 | 16390921 | There are also occasional reports of prenatal diagnosis of IAD by findings on the maternal triple-marker screen (TMST), a combined serum analyte test that measures levels of alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol for the detection of Down syndrome and open neural-tube defects. |
| 7 | 16390921 | A low estriol level in the context of normal fetal sonography and growth, after exclusion of placental sulfatase deficiency and Smith-Lemli-Opitz syndrome, should raise the suspicion of deficient fetal steroidogenesis, which leads to decreased production of adrenal dehydroepiandrosterone sulfate. |
| 8 | 16390921 | Normal levels of steroid sulfatase activity and 7-dehydrocholesterol ruled out X-linked ichthyosis and Smith-Lemli-Opitz syndrome, respectively. |
| 9 | 18704836 | On the other hand, E1S may be converted locally to free active estrogens via the action of steroid sulfatase (StS), which has been detected in specific parts of the bovine caruncular epithelium. |
| 10 | 18704836 | The down-regulation of P450scc and P450c17 and the up-regulation of 3beta-HSD and aromatase during the differentiation of TGC from UTC in parallel with the up-regulation of ER beta and estrogen sulfotransferase in maturing TGC suggests a function of placental estrogens primarily as autoor intracrine regulators during this process and assigns to conjugated placental estrogens a role as inactivated by-products of TGC differentiation intended for excretion. |
| 11 | 23340970 | X-Linked ichthyosis (XRI) is a keratinisation disorder caused by a mutation of the steroid sulfatase gene. |