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Gene Information
Gene symbol: STX2
Gene name: syntaxin 2
HGNC ID: 3403
Synonyms: EPM
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CPM | 1 hits |
| 2 | STX1A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11512412 | CPM was found in four cases (in two of them extrapontine lesions were considered as resulting from Wilson disease), CPM and EPM in three patients. |
| 2 | 17425961 | Extrapontine and central pontine myelinolysis (EPM/CPM) are rare events in pediatric neurology but can have devastating consequences. |
| 3 | 17496234 | The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1. |
| 4 | 17496234 | We reported that syntaxin-1A binds nucleotide binding folds of sulfonylurea receptor 1 (SUR1) in beta-cells to inhibit K(ATP) channels. |
| 5 | 17496234 | Whole-cell and inside-out patch-clamp electrophysiology was used to examine the effects of glutathione S-transferase (GST)-syntaxin-1A dialysis or green fluorescence protein/syntaxin-1A cotransfection on NNC55-0462 actions. |
| 6 | 17496234 | Dialysis of GST-syntaxin-1A into the cell cytoplasm reduced both potency and efficacy of extracellularly perfused NNC55-0462 in a HEK cell line stably expressing Kir6.2/SUR1 (BA8 cells) and in rat islet beta-cells. |
| 7 | 17496234 | Moreover, inside-out membrane patches excised from BA8 cells showed that both GST-syntaxin-1A and its H3 domain inhibited K(ATP) channels previously activated by NNC55-0462. |
| 8 | 17496234 | This action on K(ATP) channels is isoform-specific to syntaxin-1A because syntaxin-2 was without effect. |
| 9 | 17496234 | Furthermore, the parent compound diazoxide showed similar sensitivity to GST-syntaxin-1A inhibition. |