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Gene Information
Gene symbol: TAC3
Gene name: tachykinin 3
HGNC ID: 11521
Synonyms: ZNEUROK1, NKB
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GNRH1 | 1 hits |
| 2 | KISS1 | 1 hits |
| 3 | KISS1R | 1 hits |
| 4 | LEP | 1 hits |
| 5 | TAC1 | 1 hits |
| 6 | TACR3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8672532 | Binding of 125I-BH-SP was saturable, reversible, time- and temperature-dependent and was inhibited by several SP-related peptides with relative potencies of SP = physalaemin (IC50:0.19 nM) > SP methyl ester (SP-ME) (IC50:3.3 nM) > eledoisin (IC50:6.1 nM) > neurokinin A (NKA) (IC50: 65 nM) > neurokinin B (NKB) (IC50:80 nM). |
| 2 | 8672532 | Phospholipase C activating agents (carbachol, CCK-8), adenylate cyclase activating agents (secretin, VIP), TPA and the calcium ionophore, A23187, all inhibited the binding of 125I-BH-SP and it was due to inhibition of ligand internalization with no change in surface bound parameters. |
| 3 | 8672532 | In conclusion, the present study demonstrates that chief cells possess a NK1 subtype of tachykinin receptor, occupation of the low affinity sites of this receptor cause calcium mobilization and pepsinogen secretion, and that binding to this receptor is regulated by agents that activate phospholipase C, adenylate cyclase, protein kinase C and calcium mobilization. |
| 4 | 22229029 | Developmental defects of GnRH neurons and the olfactory bulb are associated with hyposmia, rarely associated with the clinical phenotypes of synkinesia, cleft palate, ear anomalies, or choanal atresia, and may be due to mutations of KAL1, FGFR1/FGF8, PROKR2/PROK2, or CHD7. |
| 5 | 22229029 | Impaired GnRH secretion in normosmic patients with IHH may be caused by deficient hypothalamic GPR54/KISS1, TACR3/TAC3, and leptinR/leptin signalling or mutations within the GNRH1 gene itself. |