Ignet

Gene Information

Gene symbol: TBP

Gene name: TATA box binding protein

HGNC ID: 11588

Synonyms: TFIID

Related Genes

#	Gene Symbol	Number of hits
1	C6orf208	1 hits
2	C6orf70	1 hits
3	CCR6	1 hits
4	CDK7	1 hits
5	CIDEA	1 hits
6	CREBBP	1 hits
7	DLL1	1 hits
8	EIF4ENIF1	1 hits
9	EP300	1 hits
10	FAM120B	1 hits
11	GAPDH	1 hits
12	GTF2A1	1 hits
13	GTF2B	1 hits
14	HMBS	1 hits
15	HPRT1	1 hits
16	LACE1	1 hits
17	LEF1	1 hits
18	PDCD2	1 hits
19	PHF10	1 hits
20	PSMB1	1 hits
21	RNF216	1 hits
22	RPS27A	1 hits
23	SDHA	1 hits
24	SERPINH1	1 hits
25	SP1	1 hits
26	SRY	1 hits
27	TAF1	1 hits
28	TAF8	1 hits
29	TBPL1	1 hits
30	TP53	1 hits
31	UBL5	1 hits
32	YWHAZ	1 hits

Related Sentences

#	PMID	Sentence
1	1441755	AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases.
2	1441755	This gene, AFG1 for ATPase family gene, also has substantial homology to these proteins outside the ATPase domain.
3	1441755	AFG1 is located on chromosome V immediately centromere-proximal to MAK10.
4	7547937	The structural features of the DNA complexed to SRY are remarkably similar, but not identical, to those of DNA complexed to the TATA-binding protein (TBP).
5	8710868	Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.
6	8710868	The insulin-like growth factor I receptor (IGF-I-R) plays a critical role in transformation events.
7	8710868	This effect of p53 is mediated at the level of transcription and it involves interaction with TBP, the TATA box-binding component of TFIID.
8	9646864	These include TATA-box-binding protein, integration host factor (IHF), high mobility group I(Y)[HMG I(Y)], and the HMG-box-containing proteins SRY and LEF-1.
9	9918715	We suggest that MotA and AsiA may function like certain eukaryotic TAFs (TATA binding protein (TBP) associated factors) whose binding to TBP results in transcription from new core promoter sequences.
10	10468567	We demonstrate that the recruitment of promoter-proximal activator Sp1, and the components of the basal transcription factors such as TBP, TFIIB, and Cdk7, is enhanced with thyroid hormone activation.
11	10468567	We also show that Sp1 bound to the promoter is essential for the DNA looping and recruitment of basal transcription factors such as TFIIB and Cdk7 but not for recruitment of TBP.
12	14726532	The general transcription factor TFIID sets the mRNA start site and consists of TATA-binding protein and associated factors (TAF(II)s), some of which are also present in SPT-ADA-GCN5 (SAGA)-related complexes.
13	14726532	In yeast, results of multiple studies indicate that TFIID-specific TAF(II)s are not required for the transcription of most genes, implying that intact TFIID may have a surprisingly specialized role in transcription.
14	14726532	Previously, we investigated functions of four shared TFIID/SAGA TAF(II)s in Caenorhabditis elegans.
15	14726532	Whereas TAF-4 was required for essentially all embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple developmental and other metazoan-specific promoters.
16	14726532	Here we show evidence that in C. elegans embryos transcription of most genes requires TFIID-specific TAF-1.
17	14726532	TAF-2, which binds core promoters with TAF-1, appears to be required for a similarly substantial proportion of transcription.
18	14726532	C. elegans TAF-1 overlaps functionally with the coactivator p300/CBP (CBP-1), and at some genes it is required along with the TBP-like protein TLF(TRF2).
19	14726532	We conclude that during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development and that TFIID and TLF may act together at certain promoters.
20	14726532	The general transcription factor TFIID sets the mRNA start site and consists of TATA-binding protein and associated factors (TAF(II)s), some of which are also present in SPT-ADA-GCN5 (SAGA)-related complexes.
21	14726532	In yeast, results of multiple studies indicate that TFIID-specific TAF(II)s are not required for the transcription of most genes, implying that intact TFIID may have a surprisingly specialized role in transcription.
22	14726532	Previously, we investigated functions of four shared TFIID/SAGA TAF(II)s in Caenorhabditis elegans.
23	14726532	Whereas TAF-4 was required for essentially all embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple developmental and other metazoan-specific promoters.
24	14726532	Here we show evidence that in C. elegans embryos transcription of most genes requires TFIID-specific TAF-1.
25	14726532	TAF-2, which binds core promoters with TAF-1, appears to be required for a similarly substantial proportion of transcription.
26	14726532	C. elegans TAF-1 overlaps functionally with the coactivator p300/CBP (CBP-1), and at some genes it is required along with the TBP-like protein TLF(TRF2).
27	14726532	We conclude that during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development and that TFIID and TLF may act together at certain promoters.
28	14726532	The general transcription factor TFIID sets the mRNA start site and consists of TATA-binding protein and associated factors (TAF(II)s), some of which are also present in SPT-ADA-GCN5 (SAGA)-related complexes.
29	14726532	In yeast, results of multiple studies indicate that TFIID-specific TAF(II)s are not required for the transcription of most genes, implying that intact TFIID may have a surprisingly specialized role in transcription.
30	14726532	Previously, we investigated functions of four shared TFIID/SAGA TAF(II)s in Caenorhabditis elegans.
31	14726532	Whereas TAF-4 was required for essentially all embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple developmental and other metazoan-specific promoters.
32	14726532	Here we show evidence that in C. elegans embryos transcription of most genes requires TFIID-specific TAF-1.
33	14726532	TAF-2, which binds core promoters with TAF-1, appears to be required for a similarly substantial proportion of transcription.
34	14726532	C. elegans TAF-1 overlaps functionally with the coactivator p300/CBP (CBP-1), and at some genes it is required along with the TBP-like protein TLF(TRF2).
35	14726532	We conclude that during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development and that TFIID and TLF may act together at certain promoters.
36	14726532	The general transcription factor TFIID sets the mRNA start site and consists of TATA-binding protein and associated factors (TAF(II)s), some of which are also present in SPT-ADA-GCN5 (SAGA)-related complexes.
37	14726532	In yeast, results of multiple studies indicate that TFIID-specific TAF(II)s are not required for the transcription of most genes, implying that intact TFIID may have a surprisingly specialized role in transcription.
38	14726532	Previously, we investigated functions of four shared TFIID/SAGA TAF(II)s in Caenorhabditis elegans.
39	14726532	Whereas TAF-4 was required for essentially all embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple developmental and other metazoan-specific promoters.
40	14726532	Here we show evidence that in C. elegans embryos transcription of most genes requires TFIID-specific TAF-1.
41	14726532	TAF-2, which binds core promoters with TAF-1, appears to be required for a similarly substantial proportion of transcription.
42	14726532	C. elegans TAF-1 overlaps functionally with the coactivator p300/CBP (CBP-1), and at some genes it is required along with the TBP-like protein TLF(TRF2).
43	14726532	We conclude that during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development and that TFIID and TLF may act together at certain promoters.
44	14726532	The general transcription factor TFIID sets the mRNA start site and consists of TATA-binding protein and associated factors (TAF(II)s), some of which are also present in SPT-ADA-GCN5 (SAGA)-related complexes.
45	14726532	In yeast, results of multiple studies indicate that TFIID-specific TAF(II)s are not required for the transcription of most genes, implying that intact TFIID may have a surprisingly specialized role in transcription.
46	14726532	Previously, we investigated functions of four shared TFIID/SAGA TAF(II)s in Caenorhabditis elegans.
47	14726532	Whereas TAF-4 was required for essentially all embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple developmental and other metazoan-specific promoters.
48	14726532	Here we show evidence that in C. elegans embryos transcription of most genes requires TFIID-specific TAF-1.
49	14726532	TAF-2, which binds core promoters with TAF-1, appears to be required for a similarly substantial proportion of transcription.
50	14726532	C. elegans TAF-1 overlaps functionally with the coactivator p300/CBP (CBP-1), and at some genes it is required along with the TBP-like protein TLF(TRF2).
51	14726532	We conclude that during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development and that TFIID and TLF may act together at certain promoters.
52	14726532	The general transcription factor TFIID sets the mRNA start site and consists of TATA-binding protein and associated factors (TAF(II)s), some of which are also present in SPT-ADA-GCN5 (SAGA)-related complexes.
53	14726532	In yeast, results of multiple studies indicate that TFIID-specific TAF(II)s are not required for the transcription of most genes, implying that intact TFIID may have a surprisingly specialized role in transcription.
54	14726532	Previously, we investigated functions of four shared TFIID/SAGA TAF(II)s in Caenorhabditis elegans.
55	14726532	Whereas TAF-4 was required for essentially all embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple developmental and other metazoan-specific promoters.
56	14726532	Here we show evidence that in C. elegans embryos transcription of most genes requires TFIID-specific TAF-1.
57	14726532	TAF-2, which binds core promoters with TAF-1, appears to be required for a similarly substantial proportion of transcription.
58	14726532	C. elegans TAF-1 overlaps functionally with the coactivator p300/CBP (CBP-1), and at some genes it is required along with the TBP-like protein TLF(TRF2).
59	14726532	We conclude that during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development and that TFIID and TLF may act together at certain promoters.
60	15848047	This is within the region which harbours a cluster of three genes encoding proteasome subunit beta 1 (PMSB1), TATA-box binding protein (TBP) and a homologue of mouse programming cell death activator 2 (PDCD2).
61	15848047	G/A1180 dimorphism and two other SNPs, C/T771 TBP and G/T(-271) PDCD2, were shown to share three common haplotypes, two of which (A-T-G and A-T-T) have been associated with higher development risk of T1D.
62	15848047	These findings suggest that the PDCD2 gene is a likely susceptibility gene for T1D within IDDM8.
63	15848047	This is within the region which harbours a cluster of three genes encoding proteasome subunit beta 1 (PMSB1), TATA-box binding protein (TBP) and a homologue of mouse programming cell death activator 2 (PDCD2).
64	15848047	G/A1180 dimorphism and two other SNPs, C/T771 TBP and G/T(-271) PDCD2, were shown to share three common haplotypes, two of which (A-T-G and A-T-T) have been associated with higher development risk of T1D.
65	15848047	These findings suggest that the PDCD2 gene is a likely susceptibility gene for T1D within IDDM8.
66	15850778	Using a much larger sample of T1D families than those studied by others, and by extensive re-sequencing of nine other genes in the proximity, in which we identified 279 polymorphisms, 83 of which were genotyped in up to 725 T1D multiplex and simplex families, we obtained no evidence for association of the TBP CAG/CAA (glutamine) microsatellite repeat sequence with disease, or for nine other genes, PDCD2, PSMB1, KIAA1838, DLL1, dJ894D12.4, FLJ25454, FLJ13162, FLJ11152, PHF10 and CCR6.
67	16085039	We sought to identify candidate control genes by analyzing seven functionally distinct housekeeping genes (B2M, GAPDH, HMBS, HPRT, SDHA, TBP, YWHAZ) for their expression stability and level in the placenta. mRNA isolated from 20 placentae was analyzed for gene expression using RT-PCR.
68	16085039	TBP and SDHA were the most stable, with an average expression stability of M = 0.43, followed by YWHAZ (M = 0.44) > HPRT (M = 0.53) > HMBS (M = 0.57) > GAPDH (M = 0.61) > B2M (M = 0.69).
69	16085039	By using TBP, SDHA and YWHAZ, with greater expression stability than those housekeeping genes commonly used in placenta studies, gene expression profile comparisons will have more sensitivity and specificity.
70	16085039	We sought to identify candidate control genes by analyzing seven functionally distinct housekeeping genes (B2M, GAPDH, HMBS, HPRT, SDHA, TBP, YWHAZ) for their expression stability and level in the placenta. mRNA isolated from 20 placentae was analyzed for gene expression using RT-PCR.
71	16085039	TBP and SDHA were the most stable, with an average expression stability of M = 0.43, followed by YWHAZ (M = 0.44) > HPRT (M = 0.53) > HMBS (M = 0.57) > GAPDH (M = 0.61) > B2M (M = 0.69).
72	16085039	By using TBP, SDHA and YWHAZ, with greater expression stability than those housekeeping genes commonly used in placenta studies, gene expression profile comparisons will have more sensitivity and specificity.
73	16945141	The region contains a number of potential candidate genes, including programmed cell death 2 (PDCD2), the proteosome subunit beta type 1 (PSMB1), delta-like ligand 1 (DLL-1) and TATA box-binding protein (TBP) amongst others.
74	19609011	Regarding protein metabolism a marked downregulation in gene transcripts for: general transcription factor IIA1 (-1.88, P=0.016309), TATA box binding protein (-2.17, P=0.037373), eukaryotic translation initiation factor 4E nuclear import factor 1 (-1.61, P=0.037373), eukaryotic translation elongation factor Ibeta2 (-1.95, P=0.010406), ubiquitin-like 5 (-1.67, P=0.024975) and ubiquitin conjugating enzyme 7 interacting protein 1 (-1.68, P=0.016309) was observed.
75	19609011	STZ-diabetes caused a drop in the expression of myogenin, whereas myostatin level was significantly elevated.
76	19609011	In conclusion, 1) STZ-diabetes attenuates expression of gene transcripts involved in the process of transcription and translation, which may affect skeletal muscle protein synthesis and lead to nitrogen imbalance, 2) impaired expression of gene transcripts involved in the regulation and activity of the ubiquitin-proteasome pathway may contribute to attenuation of mechanisms eliminating damaged proteins in STZ-diabetes, 3) changes in the expression of key myogenic factors, manifested by a decrease in myogenin level and enhancement of myostatin expression may be one of the mechanisms limiting skeletal muscle growth and regeneration associated with diabetes.
77	23507230	We examined the expression of the following reference genes in the offspring of a rodent maternal low-protein diet model: β-actin, hypoxanthine phosphoribosyltransferase 1, TATA-box-binding protein, glyceraldehyde-3-phosphate dehydrogenase, and glucuronidase-β in brain, heart, kidneys, and intestines.
78	23507230	Glyceraldehyde-3-phosphate dehydrogenase and glucuronidase-β were found to be the least affected by these variables, whereas hypoxanthine phosphoribosyltransferase 1 was the most inconsistent.