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Gene Information
Gene symbol: TBX5
Gene name: T-box 5
HGNC ID: 11604
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HIF1A | 1 hits |
| 2 | MEF2C | 1 hits |
| 3 | NKX2-5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23619295 | Using genome-wide expression profiling, we previously demonstrated that exposure to maternal diabetes resulted in dysregulation of the hypoxia-inducible factor 1 (HIF-1) pathway in the developing embryo. |
| 2 | 23619295 | We thus considered a possible link between HIF-1-regulated pathways and the development of congenital malformations. |
| 3 | 23619295 | HIF-1α heterozygous-null (Hif1a(+/-)) and wild type (Wt) littermate embryos were exposed to the intrauterine environment of a diabetic mother to analyze the frequency and morphology of congenital defects, and assess gene expression changes in Wt and Hif1a(+/-) embryos. |
| 4 | 23619295 | We also detected significant differences in the expression of key cardiac transcription factors, including Nkx2.5, Tbx5, and Mef2C, in diabetes-exposed Hif1a(+/-) embryonic hearts compared to Wt littermates. |